Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3901633..3902258 Replicon chromosome
Accession NZ_CP077806
Organism Klebsiella pneumoniae strain FF979

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KU665_RS18575 Protein ID WP_040215784.1
Coordinates 3901633..3902016 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag KU665_RS18580 Protein ID WP_004150355.1
Coordinates 3902016..3902258 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU665_RS18560 (KU665_18520) 3898998..3899900 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
KU665_RS18565 (KU665_18525) 3899897..3900532 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
KU665_RS18570 (KU665_18530) 3900529..3901458 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
KU665_RS18575 (KU665_18535) 3901633..3902016 - 384 WP_040215784.1 type II toxin-antitoxin system VapC family toxin Toxin
KU665_RS18580 (KU665_18540) 3902016..3902258 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
KU665_RS18585 (KU665_18545) 3902463..3903380 + 918 WP_251335798.1 alpha/beta hydrolase -
KU665_RS18590 (KU665_18550) 3903394..3904335 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
KU665_RS18595 (KU665_18555) 3904380..3904817 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
KU665_RS18600 (KU665_18560) 3904814..3905665 - 852 WP_251335799.1 virulence factor BrkB family protein -
KU665_RS18605 (KU665_18565) 3905659..3906258 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14324.57 Da        Isoelectric Point: 6.7186

>T207867 WP_040215784.1 NZ_CP077806:c3902016-3901633 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRCEAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T207867 NZ_CP103529:2826960-2827067 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT207867 WP_004150355.1 NZ_CP077806:c3902258-3902016 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT207867 NZ_CP103529:c2826913-2826847 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References