Detailed information of TA system TA207866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3582566..3584247
• Replicon: chromosome
• Accession: NZ_CP077806
• Organism: Klebsiella pneumoniae strain FF979

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KU665_RS17100
• Protein ID: WP_221012720.1
• Coordinates: 3582566..3583483 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KU665_RS17105
• Protein ID: WP_004177809.1
• Coordinates: 3583489..3584247 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU665_RS17080 (KU665_17035)	3577872..3579392	+	1521	WP_023342439.1	sugar ABC transporter ATP-binding protein	-
KU665_RS17085 (KU665_17040)	3579389..3580387	+	999	WP_002885172.1	ribose ABC transporter permease	-
KU665_RS17090 (KU665_17045)	3580418..3581359	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KU665_RS17095 (KU665_17050)	3581434..3582441	+	1008	WP_023342438.1	carbohydrate kinase family protein	-
KU665_RS17100 (KU665_17055)	3582566..3583483	-	918	WP_221012720.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KU665_RS17105 (KU665_17060)	3583489..3584247	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KU665_RS17110 (KU665_17065)	3584333..3585061	-	729	WP_200544236.1	response regulator transcription factor	-
KU665_RS17115 (KU665_17070)	3585334..3587481	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
KU665_RS17120 (KU665_17075)	3587478..3587621	-	144	WP_170918815.1	hypothetical protein	-
KU665_RS17125 (KU665_17080)	3588407..3589093	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34678.16 Da
• Isoelectric Point: 5.4705

>T207866 WP_221012720.1 NZ_CP077806:c3583483-3582566 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKCGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T207866 NZ_CP103529:c2613998-2613822 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT207866 WP_004177809.1 NZ_CP077806:c3584247-3583489 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT207866 NZ_CP103529:c2613776-2613360 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: A6TH05