Detailed information of TA system TA207862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1340065..1341653
• Replicon: chromosome
• Accession: NZ_CP077806
• Organism: Klebsiella pneumoniae strain FF979

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KU665_RS06420
• Protein ID: WP_251336118.1
• Coordinates: 1340065..1341387 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KU665_RS06425
• Protein ID: WP_004176198.1
• Coordinates: 1341387..1341653 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU665_RS06400 (KU665_06390)	1336627..1336875	+	249	WP_002904810.1	hypothetical protein	-
KU665_RS06405 (KU665_06395)	1337165..1337383	+	219	WP_002904808.1	ParD-like family protein	-
KU665_RS06410 (KU665_06400)	1337364..1338146	+	783	WP_004179825.1	type I methionyl aminopeptidase	-
KU665_RS06415 (KU665_06405)	1338756..1340048	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KU665_RS06420 (KU665_06410)	1340065..1341387	-	1323	WP_251336118.1	type II toxin-antitoxin system HipA family toxin	Toxin
KU665_RS06425 (KU665_06415)	1341387..1341653	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KU665_RS06430 (KU665_06420)	1342039..1342365	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
KU665_RS06435 (KU665_06425)	1342362..1342862	-	501	WP_004190169.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KU665_RS06440 (KU665_06430)	1342840..1344219	-	1380	WP_004176204.1	nucleobase:cation symporter-2 family protein	-
KU665_RS06445 (KU665_06435)	1344565..1345719	+	1155	WP_023341545.1	FAD-dependent urate hydroxylase HpxO	-
KU665_RS06450 (KU665_06440)	1345700..1346623	-	924	WP_251336119.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49081.39 Da
• Isoelectric Point: 7.5366

>T207862 WP_251336118.1 NZ_CP077806:c1341387-1340065 [Klebsiella pneumoniae]
MATLTTWMNNVRVGSLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T207862 NZ_CP103529:1934826-1935080 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT207862 WP_004176198.1 NZ_CP077806:c1341653-1341387 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT207862 NZ_CP103529:1934578-1934829 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA