Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 578473..579098 Replicon chromosome
Accession NZ_CP077805
Organism Klebsiella variicola strain FF907

Toxin (Protein)


Gene name vapC Uniprot ID A0A1F2M041
Locus tag KU664_RS02720 Protein ID WP_008807903.1
Coordinates 578473..578856 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KU664_RS02725 Protein ID WP_162550505.1
Coordinates 578856..579098 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU664_RS02705 (KU664_02685) 575839..576741 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
KU664_RS02710 (KU664_02690) 576738..577373 + 636 WP_008807902.1 formate dehydrogenase cytochrome b556 subunit -
KU664_RS02715 (KU664_02695) 577370..578299 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
KU664_RS02720 (KU664_02700) 578473..578856 - 384 WP_008807903.1 type II toxin-antitoxin system VapC family toxin Toxin
KU664_RS02725 (KU664_02705) 578856..579098 - 243 WP_162550505.1 CopG family transcriptional regulator Antitoxin
KU664_RS02730 (KU664_02710) 579303..580220 + 918 WP_023296845.1 alpha/beta hydrolase -
KU664_RS02735 (KU664_02715) 580235..581176 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
KU664_RS02740 (KU664_02720) 581221..581658 - 438 WP_023296844.1 D-aminoacyl-tRNA deacylase -
KU664_RS02745 (KU664_02725) 581655..582515 - 861 WP_008807907.1 virulence factor BrkB family protein -
KU664_RS02750 (KU664_02730) 582509..583108 - 600 WP_008807908.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T207835 WP_008807903.1 NZ_CP077805:c578856-578473 [Klebsiella variicola]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYELHPE

Download         Length: 384 bp

>T207835 NZ_CP103521:2852281-2852388 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9524.80 Da        Isoelectric Point: 4.2500

>AT207835 WP_162550505.1 NZ_CP077805:c579098-578856 [Klebsiella variicola]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDLAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT207835 NZ_CP103521:c2852228-2852167 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2M041

Antitoxin

Source ID Structure

References