Detailed information of TA system TA207834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 95083..95599
• Replicon: chromosome
• Accession: NZ_CP077805
• Organism: Klebsiella variicola strain FF907

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KU664_RS00440
• Protein ID: WP_022065401.1
• Coordinates: 95083..95367 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: KU664_RS00445
• Protein ID: WP_002886901.1
• Coordinates: 95357..95599 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU664_RS00425 (KU664_00405)	90185..91840	+	1656	WP_251346943.1	alpha,alpha-phosphotrehalase	-
KU664_RS00430 (KU664_00410)	92226..94364	+	2139	WP_044614392.1	anaerobic ribonucleoside-triphosphate reductase	-
KU664_RS00435 (KU664_00415)	94615..95079	+	465	WP_022065402.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KU664_RS00440 (KU664_00420)	95083..95367	-	285	WP_022065401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KU664_RS00445 (KU664_00425)	95357..95599	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KU664_RS00450 (KU664_00430)	95677..97587	-	1911	WP_032731805.1	PRD domain-containing protein	-
KU664_RS00455 (KU664_00435)	97610..98764	-	1155	WP_012543086.1	lactonase family protein	-
KU664_RS00460 (KU664_00440)	98890..99630	-	741	WP_008807137.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11128.97 Da
• Isoelectric Point: 10.2849

>T207834 WP_022065401.1 NZ_CP077805:c95367-95083 [Klebsiella variicola]
MTYELEFDPRAWREWQMPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T207834 NZ_CP103521:c2591960-2591784 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT207834 WP_002886901.1 NZ_CP077805:c95599-95357 [Klebsiella variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT207834 NZ_CP103521:c2591738-2591322 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0