Detailed information of TA system TA207833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3684724..3685293
• Replicon: chromosome
• Accession: NZ_CP077803
• Organism: Rhodospirillum rubrum strain DSM 467

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KUL73_RS16480
• Protein ID: WP_237703881.1
• Coordinates: 3685099..3685293 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q2RPF3
• Locus tag: KUL73_RS16475
• Protein ID: WP_011390945.1
• Coordinates: 3684724..3685044 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUL73_RS16445 (KUL73_16445)	3680281..3681579	+	1299	WP_011390939.1	dihydroorotase	-
KUL73_RS16450 (KUL73_16450)	3681572..3682222	+	651	WP_011390940.1	glycerol-3-phosphate 1-O-acyltransferase PlsY	-
KUL73_RS16455 (KUL73_16455)	3682319..3682987	+	669	WP_011390941.1	glutathione S-transferase family protein	-
KUL73_RS16460 (KUL73_16460)	3682990..3684114	+	1125	WP_011390942.1	DNA-processing protein DprA	-
KUL73_RS16465 (KUL73_16465)	3684211..3684435	+	225	WP_011390943.1	TraY domain-containing protein	-
KUL73_RS16470 (KUL73_16470)	3684419..3684688	+	270	WP_011390944.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KUL73_RS16475 (KUL73_16475)	3684724..3685044	-	321	WP_011390945.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KUL73_RS16480 (KUL73_16480)	3685099..3685293	-	195	WP_237703881.1	type II toxin-antitoxin system HicA family toxin	Toxin
KUL73_RS16485 (KUL73_16485)	3685642..3686649	+	1008	WP_014626531.1	ABC transporter substrate-binding protein	-
KUL73_RS16490 (KUL73_16490)	3686665..3688389	+	1725	WP_011390948.1	iron ABC transporter permease	-
KUL73_RS16495 (KUL73_16495)	3688377..3689456	+	1080	WP_011390949.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-58)

Antitoxin

• Uncharacterised protein family HicB (52-101)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 6987.04 Da
• Isoelectric Point: 9.6373

>T207833 WP_237703881.1 NZ_CP077803:c3685293-3685099 [Rhodospirillum rubrum]
MDIERLFLALGGTVDDSREGSRVAVSLNGIRAVFHRPHPRPCTEKGALRSVRRFLVAAGIVEEG

Nucleotide

• Length: 195 bp

>T207833 NZ_CP103521:2488817-2489512 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACTATTCAGGCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCG
CAGGAATACACATCAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATT
TATCCGCGACATTTTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGC
CAGAATGATTCCGGCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTG
AAACCAATGTGTTGAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11899.32 Da
• Isoelectric Point: 4.9044

>AT207833 WP_011390945.1 NZ_CP077803:c3685044-3684724 [Rhodospirillum rubrum]
MKYKGYTSSAIDFDEEDKLFSGTIDGIKDVVHFAASSADDLVQAFHDSVDDYLTYCQERGEEPDKPFNGRILLRTSPELH
RKAAMVAAREGLSLSKWLSRIIDRAA

Nucleotide

• Length: 321 bp

>AT207833 NZ_CP103521:2488551-2488817 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: Q2RPF3