Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3547205..3547783 Replicon chromosome
Accession NZ_CP077803
Organism Rhodospirillum rubrum strain DSM 467

Toxin (Protein)


Gene name PumA Uniprot ID Q2RPR9
Locus tag KUL73_RS15890 Protein ID WP_011390829.1
Coordinates 3547205..3547501 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID Q2RPR8
Locus tag KUL73_RS15895 Protein ID WP_011390830.1
Coordinates 3547502..3547783 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUL73_RS15870 (KUL73_15870) 3543113..3543862 + 750 WP_011390825.1 electron transfer flavoprotein subunit beta/FixA family protein -
KUL73_RS15875 (KUL73_15875) 3543864..3544799 + 936 WP_011390826.1 FAD-binding protein -
KUL73_RS15880 (KUL73_15880) 3544842..3545714 + 873 WP_011390827.1 3-hydroxybutyryl-CoA dehydrogenase -
KUL73_RS15885 (KUL73_15885) 3545822..3547018 + 1197 WP_011390828.1 glycosyltransferase family 39 protein -
KUL73_RS15890 (KUL73_15890) 3547205..3547501 + 297 WP_011390829.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUL73_RS15895 (KUL73_15895) 3547502..3547783 + 282 WP_011390830.1 putative addiction module antidote protein Antitoxin
KUL73_RS15900 (KUL73_15900) 3547855..3548409 - 555 WP_011390831.1 NADPH-dependent FMN reductase -
KUL73_RS15905 (KUL73_15905) 3548500..3550002 - 1503 WP_011390832.1 ribosome biogenesis GTPase Der -
KUL73_RS15910 (KUL73_15910) 3550097..3551464 - 1368 WP_011390833.1 PQQ-binding-like beta-propeller repeat protein -
KUL73_RS15915 (KUL73_15915) 3551454..3552215 - 762 WP_011390834.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10751.35 Da        Isoelectric Point: 7.9765

>T207831 WP_011390829.1 NZ_CP077803:3547205-3547501 [Rhodospirillum rubrum]
MFDVRQTEAFEEWLAGLADEKAGARIAQRIVRLRNGLFGDVKPVGDGVSELRVDDGPGYRLYFVQRGTTLIILLCGGIKG
AQRRDIARAKAMAAEVES

Download         Length: 297 bp

>T207831 NZ_CP103521:2123461-2123564 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9832.14 Da        Isoelectric Point: 5.7973

>AT207831 WP_011390830.1 NZ_CP077803:3547502-3547783 [Rhodospirillum rubrum]
MIKTKPFDAARHLTSPEAQQDLLNDAFASGSASYIADALGVIARARGMTDVAREAGVTREALYKSLSEDGDPRLTTLLGV
ARALGVTLTARLD

Download         Length: 282 bp

>AT207831 NZ_CP103521:c2123602-2123331 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2RPR9

Antitoxin

Source ID Structure
AlphaFold DB Q2RPR8

References