Detailed information of TA system TA207829

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2030609..2031262
• Replicon: chromosome
• Accession: NZ_CP077803
• Organism: Rhodospirillum rubrum strain DSM 467

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q2RTK6
• Locus tag: KUL73_RS09005
• Protein ID: WP_011389492.1
• Coordinates: 2031068..2031262 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: Q2RTK7
• Locus tag: KUL73_RS09000
• Protein ID: WP_011389491.1
• Coordinates: 2030609..2030995 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUL73_RS08960 (KUL73_08960)	2025829..2026356	+	528	WP_011389483.1	thermonuclease family protein	-
KUL73_RS08965 (KUL73_08965)	2026377..2026709	-	333	WP_011389484.1	hypothetical protein	-
KUL73_RS08970 (KUL73_08970)	2026800..2027261	-	462	WP_011389485.1	LysM domain-containing protein	-
KUL73_RS08975 (KUL73_08975)	2027287..2028423	-	1137	WP_011389486.1	SPOR domain-containing protein	-
KUL73_RS08980 (KUL73_08980)	2028456..2028731	-	276	WP_014626238.1	hypothetical protein	-
KUL73_RS08985 (KUL73_08985)	2028894..2029658	-	765	WP_011389488.1	protein phosphatase CheZ	-
KUL73_RS08990 (KUL73_08990)	2030022..2030285	+	264	WP_011389489.1	hypothetical protein	-
KUL73_RS08995 (KUL73_08995)	2030291..2030569	+	279	WP_011389490.1	hypothetical protein	-
KUL73_RS09000 (KUL73_09000)	2030609..2030995	-	387	WP_011389491.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KUL73_RS09005 (KUL73_09005)	2031068..2031262	-	195	WP_011389492.1	type II toxin-antitoxin system HicA family toxin	Toxin
KUL73_RS09010 (KUL73_09010)	2031391..2031564	+	174	WP_158308122.1	hypothetical protein	-
KUL73_RS09015 (KUL73_09015)	2031727..2032062	+	336	WP_011389493.1	hypothetical protein	-
KUL73_RS09020 (KUL73_09020)	2032059..2032925	+	867	WP_014626239.1	tyrosine-type recombinase/integrase	-
KUL73_RS09030 (KUL73_09030)	2033311..2033817	-	507	WP_011389495.1	peptidylprolyl isomerase	-
KUL73_RS09035 (KUL73_09035)	2033914..2034432	-	519	WP_011389496.1	pantetheine-phosphate adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2030609..2040778	10169

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-120)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7295.51 Da
• Isoelectric Point: 11.4226

>T207829 WP_011389492.1 NZ_CP077803:c2031262-2031068 [Rhodospirillum rubrum]
MDSREVVKRLKADGWRVVDQPGSHLQLKHPIKRGRVTVPHPEKDLKPGTLRSIEKQSGVSMRKT

Nucleotide

• Length: 195 bp

>T207829 NZ_CP103521:1919011-1919262 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13338.09 Da
• Isoelectric Point: 3.7858

>AT207829 WP_011389491.1 NZ_CP077803:c2030995-2030609 [Rhodospirillum rubrum]
MNYTYAVVIETDDLGGFSAFFPDLPGCVGAGDSVEACFQDALDALALHLAGMIEDGDSLPAPTPLSDVEVDPDIQVAAIL
LASVPVTGRTMRVNITMDATLVAAIDGVTSNRSAWLADAALRALRSNR

Nucleotide

• Length: 387 bp

>AT207829 NZ_CP103521:1919259-1919513 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: Q2RTK6

Antitoxin

• AlphaFold DB: Q2RTK7