Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
| Location | 1254695..1255269 | Replicon | chromosome |
| Accession | NZ_CP077803 | ||
| Organism | Rhodospirillum rubrum strain DSM 467 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q2RVI2 |
| Locus tag | KUL73_RS05535 | Protein ID | WP_011388817.1 |
| Coordinates | 1254904..1255269 (+) | Length | 122 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q2RVI3 |
| Locus tag | KUL73_RS05530 | Protein ID | WP_011388816.1 |
| Coordinates | 1254695..1254910 (+) | Length | 72 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUL73_RS05500 (KUL73_05500) | 1249894..1250898 | - | 1005 | WP_011388811.1 | NAD(P)H-quinone oxidoreductase | - |
| KUL73_RS05505 (KUL73_05505) | 1251047..1251229 | + | 183 | WP_014626086.1 | DUF1192 family protein | - |
| KUL73_RS05510 (KUL73_05510) | 1251328..1252107 | + | 780 | WP_011388812.1 | 3-hydroxybutyrate dehydrogenase | - |
| KUL73_RS05515 (KUL73_05515) | 1252117..1252572 | + | 456 | WP_011388813.1 | thioesterase family protein | - |
| KUL73_RS05520 (KUL73_05520) | 1252576..1253559 | - | 984 | WP_011388814.1 | aldo/keto reductase | - |
| KUL73_RS05525 (KUL73_05525) | 1253665..1254600 | + | 936 | WP_011388815.1 | LysR family transcriptional regulator | - |
| KUL73_RS05530 (KUL73_05530) | 1254695..1254910 | + | 216 | WP_011388816.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| KUL73_RS05535 (KUL73_05535) | 1254904..1255269 | + | 366 | WP_011388817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KUL73_RS05540 (KUL73_05540) | 1255307..1255651 | + | 345 | WP_011388818.1 | LysR substrate-binding domain-containing protein | - |
| KUL73_RS05545 (KUL73_05545) | 1255826..1256122 | + | 297 | WP_011388819.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KUL73_RS05550 (KUL73_05550) | 1256131..1256439 | + | 309 | WP_014626089.1 | HigA family addiction module antitoxin | - |
| KUL73_RS05555 (KUL73_05555) | 1256594..1257379 | + | 786 | WP_011388821.1 | ATP-binding cassette domain-containing protein | - |
| KUL73_RS05560 (KUL73_05560) | 1257376..1258077 | + | 702 | WP_011388822.1 | GTP-binding protein | - |
| KUL73_RS05565 (KUL73_05565) | 1258079..1259260 | + | 1182 | WP_011388823.1 | cysteine desulfurase family protein | - |
| KUL73_RS05570 (KUL73_05570) | 1259304..1260029 | + | 726 | WP_011388824.1 | (Fe-S)-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 122 a.a. Molecular weight: 13667.80 Da Isoelectric Point: 5.7614
>T207827 WP_011388817.1 NZ_CP077803:1254904-1255269 [Rhodospirillum rubrum]
MVGALFDTNILIDHLNARPEASEEIERFESRAISIITWMEVMVGARADLIEPTRLFLDGFKVIALDDKIAKRAVDLRRAH
RIKLPDAVIWATAQTTGRLLVTRNTKDFPPDDPGVREPYAL
MVGALFDTNILIDHLNARPEASEEIERFESRAISIITWMEVMVGARADLIEPTRLFLDGFKVIALDDKIAKRAVDLRRAH
RIKLPDAVIWATAQTTGRLLVTRNTKDFPPDDPGVREPYAL
Download Length: 366 bp
>T207827 NZ_CP103521:1039248-1039583 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG
Antitoxin
Download Length: 72 a.a. Molecular weight: 8038.06 Da Isoelectric Point: 7.2023
>AT207827 WP_011388816.1 NZ_CP077803:1254695-1254910 [Rhodospirillum rubrum]
VRALVDMSDAQIEALDTLAKRVGQSRAALIRAAIDDYLDRHHREQVADGFGLWGKRKVDGLAYQEKARSEW
VRALVDMSDAQIEALDTLAKRVGQSRAALIRAAIDDYLDRHHREQVADGFGLWGKRKVDGLAYQEKARSEW
Download Length: 216 bp
>AT207827 NZ_CP103521:1039000-1039248 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|