Detailed information of TA system TA207826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 969975..970867
• Replicon: chromosome
• Accession: NZ_CP077803
• Organism: Rhodospirillum rubrum strain DSM 467

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: Q2RW79
• Locus tag: KUL73_RS04260
• Protein ID: WP_011388570.1
• Coordinates: 969975..970499 (-)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: Q2RW78
• Locus tag: KUL73_RS04265
• Protein ID: WP_011388571.1
• Coordinates: 970496..970867 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUL73_RS04245 (KUL73_04245)	966706..966996	+	291	WP_011388568.1	DCL family protein	-
KUL73_RS04250 (KUL73_04250)	967280..967750	-	471	WP_011388569.1	CopG family transcriptional regulator	-
KUL73_RS04255 (KUL73_04255)	967758..969749	-	1992	Protein_832	conjugal transfer protein TraG	-
KUL73_RS04260 (KUL73_04260)	969975..970499	-	525	WP_011388570.1	RES family NAD+ phosphorylase	Toxin
KUL73_RS04265 (KUL73_04265)	970496..970867	-	372	WP_011388571.1	DUF2384 domain-containing protein	Antitoxin
KUL73_RS04270 (KUL73_04270)	970994..972751	-	1758	WP_014626034.1	DUF3363 domain-containing protein	-
KUL73_RS04275 (KUL73_04275)	973217..974023	+	807	Protein_836	IS256 family transposase	-
KUL73_RS04280 (KUL73_04280)	974067..974288	-	222	Protein_837	transposase family protein	-
KUL73_RS04285 (KUL73_04285)	974798..974950	+	153	WP_158308117.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	973313..974023	710

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (15-158)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19612.07 Da
• Isoelectric Point: 4.8129

>T207826 WP_011388570.1 NZ_CP077803:c970499-969975 [Rhodospirillum rubrum]
MIVRTLGTELPEAYYRVITPEYAGTPKSGRGAARRGGRFNRPQQEALYLSANDVTALAEYKQDNPWLRPGTICTFFVAGL
HVADLSDGFDPAHWPSLWADFTIDWRAEWFDKGIEPPTWYMADDVVSADLDGILFPSQALSGGVNLVIYRSSERPETQLS
VYDPDRQLKKITLR

Nucleotide

• Length: 525 bp

>T207826 NZ_CP103521:943795-944208 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGCTTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATCAAGATGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13578.41 Da
• Isoelectric Point: 7.2025

>AT207826 WP_011388571.1 NZ_CP077803:c970867-970496 [Rhodospirillum rubrum]
MSPLFSEPLAERFREANTPYLSPAKVSELFGFRVQELAGRAHVHRNTPTARPQTPQLQQYLQNMVRVLTVATEMTGDEGR
AVFLLRNEPLRAFGYKTADTLVQEGRADAVIAYLESLTGGAAG

Nucleotide

• Length: 372 bp

>AT207826 NZ_CP103521:943548-943814 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAATTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: Q2RW79

Antitoxin

• AlphaFold DB: Q2RW78