Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 105090..105770 Replicon chromosome
Accession NZ_CP077803
Organism Rhodospirillum rubrum strain DSM 467

Toxin (Protein)


Gene name vapC Uniprot ID Q2RY99
Locus tag KUL73_RS00460 Protein ID WP_011387852.1
Coordinates 105336..105770 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q2RYA0
Locus tag KUL73_RS00455 Protein ID WP_011387851.1
Coordinates 105090..105332 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUL73_RS00440 (KUL73_00440) 100362..101603 + 1242 WP_011387848.1 TIGR03862 family flavoprotein -
KUL73_RS00445 (KUL73_00445) 101782..102804 + 1023 WP_011387849.1 zinc-binding alcohol dehydrogenase family protein -
KUL73_RS00450 (KUL73_00450) 103021..104814 + 1794 WP_014625867.1 DNA helicase RecQ -
KUL73_RS00455 (KUL73_00455) 105090..105332 + 243 WP_011387851.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KUL73_RS00460 (KUL73_00460) 105336..105770 + 435 WP_011387852.1 type II toxin-antitoxin system VapC family toxin Toxin
KUL73_RS00465 (KUL73_00465) 106146..107423 + 1278 WP_011387853.1 ABC transporter substrate-binding protein -
KUL73_RS00470 (KUL73_00470) 107469..108338 + 870 WP_011387854.1 sugar ABC transporter permease -
KUL73_RS00475 (KUL73_00475) 108335..109273 + 939 WP_011387855.1 carbohydrate ABC transporter permease -
KUL73_RS00480 (KUL73_00480) 109280..110398 + 1119 WP_011387856.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-132)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15675.14 Da        Isoelectric Point: 7.4700

>T207824 WP_011387852.1 NZ_CP077803:105336-105770 [Rhodospirillum rubrum]
MYLVDTNVLSARAPSRVAPVELIAWMDAHSAELFLSAVTVAEIEDGIAKLRREGATRKAADLMAWLDALLHLYGNRILPF
DTTLARLAGVLSDRARAQGQAPGFADIAIAATAKHHDLTILTRNVRHFDRLGVPVIDPFAALPR

Download         Length: 435 bp

>T207824 NZ_CP103521:731970-732266 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8844.18 Da        Isoelectric Point: 7.0141

>AT207824 WP_011387851.1 NZ_CP077803:105090-105332 [Rhodospirillum rubrum]
MREIQLRDAKARLSAVVDDAVRGEPAIITRHGKREAVVLSFAEWERLSQVPSFGRLLMSAPLAPDDLPPRNEAPLRDAGL

Download         Length: 243 bp

>AT207824 NZ_CP103521:732268-732663 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2RY99

Antitoxin

Source ID Structure
AlphaFold DB Q2RYA0

References