Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 774552..775203 Replicon chromosome
Accession NZ_CP077801
Organism Acinetobacter baumannii strain 40288

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag KUE09_RS03930 Protein ID WP_000838147.1
Coordinates 774552..774734 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag KUE09_RS03935 Protein ID WP_002053018.1
Coordinates 774799..775203 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUE09_RS03885 (KUE09_03885) 769881..770249 + 369 WP_025467978.1 hypothetical protein -
KUE09_RS03890 (KUE09_03890) 770305..770724 + 420 WP_002053092.1 hypothetical protein -
KUE09_RS03895 (KUE09_03895) 770724..771176 + 453 WP_002053117.1 hypothetical protein -
KUE09_RS03900 (KUE09_03900) 771241..771654 + 414 WP_031965420.1 hypothetical protein -
KUE09_RS03905 (KUE09_03905) 771620..771988 + 369 WP_114226324.1 HK97 gp10 family phage protein -
KUE09_RS03910 (KUE09_03910) 771990..772388 + 399 WP_030423713.1 phage tail terminator-like protein -
KUE09_RS03915 (KUE09_03915) 772390..772602 + 213 WP_030423712.1 hypothetical protein -
KUE09_RS03920 (KUE09_03920) 772710..773639 + 930 WP_049594449.1 phage tail tube protein -
KUE09_RS03925 (KUE09_03925) 773687..774220 + 534 WP_057691629.1 hypothetical protein -
KUE09_RS03930 (KUE09_03930) 774552..774734 + 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
KUE09_RS03935 (KUE09_03935) 774799..775203 + 405 WP_002053018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KUE09_RS03940 (KUE09_03940) 775299..775817 + 519 WP_005070358.1 DUF4468 domain-containing protein -
KUE09_RS03945 (KUE09_03945) 775914..779894 + 3981 WP_225510848.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T207822 WP_000838147.1 NZ_CP077801:774552-774734 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T207822 NZ_CP103521:217148-217255 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT207822 WP_002053018.1 NZ_CP077801:774799-775203 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT207822 NZ_CP103521:c217099-217036 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q0RVR6

References