Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 461168..461821 Replicon chromosome
Accession NZ_CP077801
Organism Acinetobacter baumannii strain 40288

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag KUE09_RS02280 Protein ID WP_000607075.1
Coordinates 461432..461821 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KUE09_RS02275 Protein ID WP_001288210.1
Coordinates 461168..461425 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUE09_RS02255 (KUE09_02255) 456684..457691 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
KUE09_RS02260 (KUE09_02260) 457710..458087 + 378 WP_001216380.1 50S ribosomal protein L17 -
KUE09_RS02265 (KUE09_02265) 458269..459759 + 1491 WP_000415123.1 NAD(P)/FAD-dependent oxidoreductase -
KUE09_RS02270 (KUE09_02270) 459808..460980 - 1173 WP_001190556.1 acyl-CoA dehydrogenase family protein -
KUE09_RS02275 (KUE09_02275) 461168..461425 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KUE09_RS02280 (KUE09_02280) 461432..461821 + 390 WP_000607075.1 membrane protein Toxin
KUE09_RS02285 (KUE09_02285) 462591..463676 + 1086 WP_000049105.1 hypothetical protein -
KUE09_RS02290 (KUE09_02290) 463754..464320 + 567 WP_000651539.1 rhombosortase -
KUE09_RS02295 (KUE09_02295) 464508..466703 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T207821 WP_000607075.1 NZ_CP077801:461432-461821 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp

>T207821 NZ_CP103521:216665-216772 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT207821 WP_001288210.1 NZ_CP077801:461168-461425 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT207821 NZ_CP103521:c216616-216553 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9G864

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References