207820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 270087..270609 Replicon plasmid pCDI231-348.3
Accession NZ_CP077784
Organism Klebsiella pneumoniae strain CDI231

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag KUM55_RS28865 Protein ID WP_004181778.1
Coordinates 270325..270609 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag KUM55_RS28860 Protein ID WP_025368601.1
Coordinates 270087..270335 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUM55_RS28840 (KUM55_28845) 265296..266132 - 837 WP_223686625.1 hypothetical protein -
KUM55_RS28845 (KUM55_28850) 266179..266532 - 354 WP_004181774.1 hypothetical protein -
KUM55_RS28850 (KUM55_28855) 266677..267663 - 987 WP_025368599.1 hypothetical protein -
KUM55_RS28855 (KUM55_28860) 267997..269796 - 1800 WP_025368600.1 ATP-dependent helicase -
KUM55_RS28860 (KUM55_28865) 270087..270335 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KUM55_RS28865 (KUM55_28870) 270325..270609 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUM55_RS28870 (KUM55_28875) 270839..272065 + 1227 WP_025368602.1 RNA-guided endonuclease TnpB family protein -
KUM55_RS28875 (KUM55_28880) 272351..272776 - 426 WP_040120489.1 IS200/IS605 family transposase -
KUM55_RS28880 (KUM55_28885) 272813..274039 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
KUM55_RS28885 (KUM55_28890) 274105..275231 - 1127 Protein_301 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / mph(A) / sul1 / qacE / dfrA5 / blaNDM-1 / aph(3')-VI / qnrS1 / mph(E) / msr(E) / armA / sul2 rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..348342 348342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T207820 WP_004181778.1 NZ_CP077784:270325-270609 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T207820 NZ_CP103521:216181-216288 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT207820 WP_025368601.1 NZ_CP077784:270087-270335 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT207820 NZ_CP103521:c216123-216069 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References