Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5267010..5267635 | Replicon | chromosome |
Accession | NZ_CP077779 | ||
Organism | Klebsiella pneumoniae strain CDI231 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | KUM55_RS25555 | Protein ID | WP_002882817.1 |
Coordinates | 5267010..5267393 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | KUM55_RS25560 | Protein ID | WP_004150355.1 |
Coordinates | 5267393..5267635 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KUM55_RS25540 (KUM55_25545) | 5264376..5265278 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
KUM55_RS25545 (KUM55_25550) | 5265275..5265910 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
KUM55_RS25550 (KUM55_25555) | 5265907..5266836 | + | 930 | WP_025368581.1 | formate dehydrogenase accessory protein FdhE | - |
KUM55_RS25555 (KUM55_25560) | 5267010..5267393 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
KUM55_RS25560 (KUM55_25565) | 5267393..5267635 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
KUM55_RS25565 (KUM55_25570) | 5267840..5268757 | + | 918 | WP_025368582.1 | alpha/beta hydrolase | - |
KUM55_RS25570 (KUM55_25575) | 5268772..5269713 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
KUM55_RS25575 (KUM55_25580) | 5269758..5270195 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
KUM55_RS25580 (KUM55_25585) | 5270192..5271052 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
KUM55_RS25585 (KUM55_25590) | 5271046..5271645 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T207816 WP_002882817.1 NZ_CP077779:c5267393-5267010 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
>T207816 NZ_CP103515:c4322918-4322745 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9567.83 Da Isoelectric Point: 4.3509
>AT207816 WP_004150355.1 NZ_CP077779:c5267635-5267393 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
Download Length: 243 bp
>AT207816 NZ_CP103515:c4323242-4322946 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |