Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4791087..4791603 Replicon chromosome
Accession NZ_CP077779
Organism Klebsiella pneumoniae strain CDI231

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag KUM55_RS23300 Protein ID WP_009486548.1
Coordinates 4791087..4791371 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KUM55_RS23305 Protein ID WP_002886901.1
Coordinates 4791361..4791603 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUM55_RS23275 (KUM55_23280) 4786504..4786767 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
KUM55_RS23280 (KUM55_23285) 4786897..4787070 + 174 WP_002886906.1 hypothetical protein -
KUM55_RS23285 (KUM55_23290) 4787073..4787816 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KUM55_RS23290 (KUM55_23295) 4788173..4790311 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KUM55_RS23295 (KUM55_23300) 4790619..4791083 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KUM55_RS23300 (KUM55_23305) 4791087..4791371 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUM55_RS23305 (KUM55_23310) 4791361..4791603 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KUM55_RS23310 (KUM55_23315) 4791681..4793591 - 1911 WP_023288161.1 PRD domain-containing protein -
KUM55_RS23315 (KUM55_23320) 4793614..4794768 - 1155 WP_002886900.1 lactonase family protein -
KUM55_RS23320 (KUM55_23325) 4794835..4795575 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T207814 WP_009486548.1 NZ_CP077779:c4791371-4791087 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T207814 NZ_CP103515:c4156006-4155656 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT207814 WP_002886901.1 NZ_CP077779:c4791603-4791361 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT207814 NZ_CP103515:c4156251-4156000 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References