Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794148..794805 Replicon chromosome
Accession NZ_CP077779
Organism Klebsiella pneumoniae strain CDI231

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KUM55_RS03950 Protein ID WP_002916310.1
Coordinates 794395..794805 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KUM55_RS03945 Protein ID WP_002916312.1
Coordinates 794148..794414 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUM55_RS03920 (KUM55_03920) 789356..790789 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
KUM55_RS03925 (KUM55_03925) 790908..791636 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KUM55_RS03930 (KUM55_03930) 791686..791997 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KUM55_RS03935 (KUM55_03935) 792161..792820 + 660 WP_002916317.1 hemolysin III family protein -
KUM55_RS03940 (KUM55_03940) 792919..793902 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KUM55_RS03945 (KUM55_03945) 794148..794414 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KUM55_RS03950 (KUM55_03950) 794395..794805 + 411 WP_002916310.1 protein YgfX Toxin
KUM55_RS03955 (KUM55_03955) 794812..795333 - 522 WP_002916308.1 flavodoxin FldB -
KUM55_RS03960 (KUM55_03960) 795434..796330 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KUM55_RS03965 (KUM55_03965) 796353..797066 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KUM55_RS03970 (KUM55_03970) 797072..798805 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T207801 WP_002916310.1 NZ_CP077779:794395-794805 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T207801 NZ_CP103515:1795274-1795528 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT207801 WP_002916312.1 NZ_CP077779:794148-794414 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207801 NZ_CP103515:1795026-1795277 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References