Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4915577..4916093 Replicon chromosome
Accession NZ_CP077773
Organism Klebsiella pneumoniae strain CDI694

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KUM43_RS24330 Protein ID WP_002886902.1
Coordinates 4915577..4915861 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KUM43_RS24335 Protein ID WP_002886901.1
Coordinates 4915851..4916093 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUM43_RS24305 (KUM43_24300) 4911061..4911324 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KUM43_RS24310 (KUM43_24305) 4911454..4911627 + 174 WP_002886906.1 hypothetical protein -
KUM43_RS24315 (KUM43_24310) 4911630..4912373 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KUM43_RS24320 (KUM43_24315) 4912730..4914868 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KUM43_RS24325 (KUM43_24320) 4915109..4915573 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KUM43_RS24330 (KUM43_24325) 4915577..4915861 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KUM43_RS24335 (KUM43_24330) 4915851..4916093 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KUM43_RS24340 (KUM43_24335) 4916171..4918081 - 1911 WP_004152270.1 PRD domain-containing protein -
KUM43_RS24345 (KUM43_24340) 4918104..4919258 - 1155 WP_002886900.1 lactonase family protein -
KUM43_RS24350 (KUM43_24345) 4919324..4920064 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T207787 WP_002886902.1 NZ_CP077773:c4915861-4915577 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T207787 NZ_CP103512:4153293-4153511 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT207787 WP_002886901.1 NZ_CP077773:c4916093-4915851 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT207787 NZ_CP103512:4152892-4153266 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References