Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876843..877497 Replicon chromosome
Accession NZ_CP077773
Organism Klebsiella pneumoniae strain CDI694

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag KUM43_RS04425 Protein ID WP_004144731.1
Coordinates 877090..877497 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KUM43_RS04420 Protein ID WP_002916312.1
Coordinates 876843..877109 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUM43_RS04395 (KUM43_04395) 871999..873432 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KUM43_RS04400 (KUM43_04400) 873551..874279 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KUM43_RS04405 (KUM43_04405) 874329..874640 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KUM43_RS04410 (KUM43_04410) 874804..875463 + 660 WP_002916317.1 hemolysin III family protein -
KUM43_RS04415 (KUM43_04415) 875614..876597 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KUM43_RS04420 (KUM43_04420) 876843..877109 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KUM43_RS04425 (KUM43_04425) 877090..877497 + 408 WP_004144731.1 protein YgfX Toxin
KUM43_RS04430 (KUM43_04430) 877504..878025 - 522 WP_002916308.1 flavodoxin FldB -
KUM43_RS04435 (KUM43_04435) 878126..879022 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KUM43_RS04440 (KUM43_04440) 879045..879758 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KUM43_RS04445 (KUM43_04445) 879764..881497 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T207775 WP_004144731.1 NZ_CP077773:877090-877497 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T207775 NZ_CP103508:c4242540-4242163 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT207775 WP_002916312.1 NZ_CP077773:876843-877109 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207775 NZ_CP103508:c4242998-4242630 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References