Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 46136..46658 | Replicon | plasmid p2_07Q015 |
| Accession | NZ_CP077762 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G3CAN5 |
| Locus tag | KTV86_RS23175 | Protein ID | WP_000220560.1 |
| Coordinates | 46136..46417 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | KTV86_RS23180 | Protein ID | WP_000121743.1 |
| Coordinates | 46407..46658 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTV86_RS23130 (KTV86_23015) | 41984..43150 | - | 1167 | WP_001576909.1 | MobP1 family relaxase | - |
| KTV86_RS23135 (KTV86_23020) | 43153..43698 | - | 546 | WP_000757693.1 | DNA distortion polypeptide 1 | - |
| KTV86_RS23140 (KTV86_23030) | 44024..44296 | - | 273 | WP_000160399.1 | hypothetical protein | - |
| KTV86_RS23145 (KTV86_23035) | 44309..44506 | - | 198 | WP_001675595.1 | hypothetical protein | - |
| KTV86_RS23150 (KTV86_23040) | 44528..44707 | - | 180 | WP_000439078.1 | hypothetical protein | - |
| KTV86_RS23155 (KTV86_23045) | 44750..45079 | - | 330 | WP_000866648.1 | hypothetical protein | - |
| KTV86_RS23160 (KTV86_23050) | 45172..45387 | - | 216 | WP_001180116.1 | hypothetical protein | - |
| KTV86_RS23165 (KTV86_23055) | 45377..45622 | - | 246 | WP_000356546.1 | hypothetical protein | - |
| KTV86_RS23170 (KTV86_23060) | 45667..45990 | - | 324 | WP_001181903.1 | hypothetical protein | - |
| KTV86_RS23175 (KTV86_23065) | 46136..46417 | - | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KTV86_RS23180 (KTV86_23070) | 46407..46658 | - | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| KTV86_RS23185 (KTV86_23075) | 47720..48574 | + | 855 | WP_001239324.1 | replication initiation protein | - |
| KTV86_RS23190 (KTV86_23080) | 48599..49045 | + | 447 | WP_001074386.1 | hypothetical protein | - |
| KTV86_RS23195 (KTV86_23085) | 49182..49538 | + | 357 | WP_001576907.1 | DNA distortion polypeptide 3 | - |
| KTV86_RS23200 (KTV86_23090) | 49535..50512 | - | 978 | WP_001579336.1 | hypothetical protein | - |
| KTV86_RS23205 (KTV86_23095) | 50537..50818 | - | 282 | WP_001185482.1 | hypothetical protein | - |
| KTV86_RS23210 (KTV86_23100) | 50918..51580 | - | 663 | WP_000516402.1 | division plane positioning ATPase MipZ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1B / ant(2'')-Ia / qacE / sul1 | - | 1..56404 | 56404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11005.83 Da Isoelectric Point: 10.5938
>T207751 WP_000220560.1 NZ_CP077762:c46417-46136 [Salmonella enterica subsp. enterica serovar Gallinarum]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
Download Length: 282 bp
>T207751 NZ_CP103503:c5259045-5258662 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT207751 WP_000121743.1 NZ_CP077762:c46658-46407 [Salmonella enterica subsp. enterica serovar Gallinarum]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT207751 NZ_CP103503:c5259287-5259045 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G3CAN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |