Detailed information of TA system TA207750

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 30240..30765
• Replicon: plasmid p1_07Q015
• Accession: NZ_CP077761
• Organism: Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: KTV86_RS22485
• Protein ID: WP_001159863.1
• Coordinates: 30460..30765 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: KTV86_RS22480
• Protein ID: WP_000813627.1
• Coordinates: 30240..30458 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTV86_RS22445 (KTV86_22340)	25267..25980	+	714	WP_000801114.1	hypothetical protein	-
KTV86_RS22450 (KTV86_22345)	26105..26689	+	585	WP_039563776.1	hypothetical protein	-
KTV86_RS22455 (KTV86_22350)	26762..26974	+	213	WP_000063791.1	FaeA/PapI family transcriptional regulator	-
KTV86_RS22460 (KTV86_22355)	27235..27396	+	162	WP_001816720.1	hypothetical protein	-
KTV86_RS22465 (KTV86_22360)	27422..28270	+	849	WP_000175397.1	SdiA-regulated domain-containing protein	-
KTV86_RS22470 (KTV86_22365)	28840..29268	-	429	WP_000812999.1	type II toxin-antitoxin system VapC family toxin	-
KTV86_RS22475 (KTV86_22370)	29265..29495	-	231	WP_001261283.1	type II toxin-antitoxin system VapB family antitoxin	-
KTV86_RS22480 (KTV86_22375)	30240..30458	+	219	WP_000813627.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
KTV86_RS22485 (KTV86_22380)	30460..30765	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
KTV86_RS22490 (KTV86_22385)	30767..31057	+	291	WP_001266176.1	hypothetical protein	-
KTV86_RS22495 (KTV86_22390)	31054..31575	+	522	WP_000198608.1	hypothetical protein	-
KTV86_RS22500 (KTV86_22395)	31610..32392	+	783	WP_000082170.1	site-specific integrase	-
KTV86_RS22505 (KTV86_22400)	32401..32952	+	552	WP_000545754.1	EAL domain-containing protein	-
KTV86_RS22510 (KTV86_22405)	33139..33627	+	489	WP_001075507.1	CaiF/GrlA family transcriptional regulator	-
KTV86_RS22515 (KTV86_22410)	33621..34083	+	463	Protein_37	hypothetical protein	-
KTV86_RS22520 (KTV86_22415)	34360..34647	-	288	WP_071777160.1	hypothetical protein	-
KTV86_RS22525 (KTV86_22420)	34803..35369	+	567	WP_001576633.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	faeH / faeI / fdeC / spvC / spvB	1..88418	88418

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11587.48 Da
• Isoelectric Point: 6.9787

>T207750 WP_001159863.1 NZ_CP077761:30460-30765 [Salmonella enterica subsp. enterica serovar Gallinarum]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI

Nucleotide

• Length: 306 bp

>T207750 NZ_CP103503:c4945621-4944704 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCATCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8328.18 Da
• Isoelectric Point: 4.5203

>AT207750 WP_000813627.1 NZ_CP077761:30240-30458 [Salmonella enterica subsp. enterica serovar Gallinarum]
MKQRITVTLDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW

Nucleotide

• Length: 219 bp

>AT207750 NZ_CP103503:c4946385-4945627 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: I3W3D5