Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 28840..29495 | Replicon | plasmid p1_07Q015 |
| Accession | NZ_CP077761 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | M7RF18 |
| Locus tag | KTV86_RS22470 | Protein ID | WP_000812999.1 |
| Coordinates | 28840..29268 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | H9AC95 |
| Locus tag | KTV86_RS22475 | Protein ID | WP_001261283.1 |
| Coordinates | 29265..29495 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTV86_RS22435 (KTV86_22330) | 24241..25005 | + | 765 | WP_000827658.1 | K88 minor fimbrial subunit faeI | - |
| KTV86_RS22440 (KTV86_22335) | 24992..25267 | + | 276 | WP_001020576.1 | hypothetical protein | - |
| KTV86_RS22445 (KTV86_22340) | 25267..25980 | + | 714 | WP_000801114.1 | hypothetical protein | - |
| KTV86_RS22450 (KTV86_22345) | 26105..26689 | + | 585 | WP_039563776.1 | hypothetical protein | - |
| KTV86_RS22455 (KTV86_22350) | 26762..26974 | + | 213 | WP_000063791.1 | FaeA/PapI family transcriptional regulator | - |
| KTV86_RS22460 (KTV86_22355) | 27235..27396 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| KTV86_RS22465 (KTV86_22360) | 27422..28270 | + | 849 | WP_000175397.1 | SdiA-regulated domain-containing protein | - |
| KTV86_RS22470 (KTV86_22365) | 28840..29268 | - | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KTV86_RS22475 (KTV86_22370) | 29265..29495 | - | 231 | WP_001261283.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KTV86_RS22480 (KTV86_22375) | 30240..30458 | + | 219 | WP_000813627.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| KTV86_RS22485 (KTV86_22380) | 30460..30765 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | - |
| KTV86_RS22490 (KTV86_22385) | 30767..31057 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| KTV86_RS22495 (KTV86_22390) | 31054..31575 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| KTV86_RS22500 (KTV86_22395) | 31610..32392 | + | 783 | WP_000082170.1 | site-specific integrase | - |
| KTV86_RS22505 (KTV86_22400) | 32401..32952 | + | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| KTV86_RS22510 (KTV86_22405) | 33139..33627 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| KTV86_RS22515 (KTV86_22410) | 33621..34083 | + | 463 | Protein_37 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | faeH / faeI / fdeC / spvC / spvB | 1..88418 | 88418 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15483.03 Da Isoelectric Point: 7.6736
>T207749 WP_000812999.1 NZ_CP077761:c29268-28840 [Salmonella enterica subsp. enterica serovar Gallinarum]
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS
Download Length: 429 bp
>T207749 NZ_CP103503:c4789293-4789009 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8737.83 Da Isoelectric Point: 4.3775
>AT207749 WP_001261283.1 NZ_CP077761:c29495-29265 [Salmonella enterica subsp. enterica serovar Gallinarum]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
Download Length: 231 bp
>AT207749 NZ_CP103503:c4789525-4789283 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | M7RF18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6X6R7C5 |