Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3277633..3278293 Replicon chromosome
Accession NZ_CP077760
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KTV86_RS15830 Protein ID WP_000244756.1
Coordinates 3277880..3278293 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KTV86_RS15825 Protein ID WP_000351186.1
Coordinates 3277633..3277899 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTV86_RS15805 (3273562) 3273562..3274995 - 1434 WP_223671680.1 6-phospho-beta-glucosidase BglA -
KTV86_RS15810 (3275153) 3275153..3275464 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KTV86_RS15815 (3275628) 3275628..3276287 + 660 WP_000250289.1 hemolysin III family protein -
KTV86_RS15820 (3276403) 3276403..3277383 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
KTV86_RS15825 (3277633) 3277633..3277899 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KTV86_RS15830 (3277880) 3277880..3278293 + 414 WP_000244756.1 protein YgfX Toxin
KTV86_RS15835 (3278346) 3278346..3278867 - 522 WP_001055885.1 flavodoxin FldB -
KTV86_RS15840 (3278980) 3278980..3279876 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KTV86_RS15845 (3279900) 3279900..3280613 + 714 WP_000745613.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KTV86_RS15850 (3280619) 3280619..3282352 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T207747 WP_000244756.1 NZ_CP077760:3277880-3278293 [Salmonella enterica subsp. enterica serovar Gallinarum]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207747 NZ_CP103503:4079935-4080153 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207747 WP_000351186.1 NZ_CP077760:3277633-3277899 [Salmonella enterica subsp. enterica serovar Gallinarum]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207747 NZ_CP103503:4079534-4079908 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References