Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2762747..2763333 Replicon chromosome
Accession NZ_CP077760
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015

Toxin (Protein)


Gene name doc Uniprot ID B5RGW8
Locus tag KTV86_RS13265 Protein ID WP_001576508.1
Coordinates 2762965..2763333 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag KTV86_RS13260 Protein ID WP_001522145.1
Coordinates 2762747..2762968 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTV86_RS13235 (2757768) 2757768..2758877 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
KTV86_RS13240 (2758937) 2758937..2759863 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KTV86_RS13245 (2759860) 2759860..2761137 + 1278 WP_000803768.1 branched chain amino acid ABC transporter permease LivM -
KTV86_RS13250 (2761134) 2761134..2761901 + 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KTV86_RS13255 (2761903) 2761903..2762616 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KTV86_RS13260 (2762747) 2762747..2762968 + 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTV86_RS13265 (2762965) 2762965..2763333 + 369 WP_001576508.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KTV86_RS13270 (2763592) 2763592..2764908 + 1317 WP_223671629.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KTV86_RS13275 (2765013) 2765013..2765900 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KTV86_RS13280 (2765897) 2765897..2766742 + 846 WP_000572197.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KTV86_RS13285 (2766744) 2766744..2767814 + 1071 WP_000907833.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2757768..2768548 10780


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13662.01 Da        Isoelectric Point: 6.7252

>T207745 WP_001576508.1 NZ_CP077760:2762965-2763333 [Salmonella enterica subsp. enterica serovar Gallinarum]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAIFRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 369 bp

>T207745 NZ_CP103503:2044442-2044544 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT207745 WP_001522145.1 NZ_CP077760:2762747-2762968 [Salmonella enterica subsp. enterica serovar Gallinarum]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT207745 NZ_CP103503:c2044551-2044406 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B5RGW8

Antitoxin

Source ID Structure

References