Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2652860..2653620 Replicon chromosome
Accession NZ_CP077760
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9NP38
Locus tag KTV86_RS12785 Protein ID WP_001272118.1
Coordinates 2653162..2653620 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B5RGM5
Locus tag KTV86_RS12780 Protein ID WP_000965887.1
Coordinates 2652860..2653147 (+) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTV86_RS12760 (2648265) 2648265..2649176 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
KTV86_RS12765 (2649186) 2649186..2651255 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
KTV86_RS12770 (2651645) 2651645..2652043 + 399 Protein_2491 IS3 family transposase -
KTV86_RS12775 (2652215) 2652215..2652682 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
KTV86_RS12780 (2652860) 2652860..2653147 + 288 WP_000965887.1 DUF1778 domain-containing protein Antitoxin
KTV86_RS12785 (2653162) 2653162..2653620 + 459 WP_001272118.1 GNAT family N-acetyltransferase Toxin
KTV86_RS12790 (2653991) 2653991..2654530 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
KTV86_RS12795 (2654704) 2654704..2654916 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
KTV86_RS12800 (2655204) 2655204..2655494 - 291 WP_000455790.1 HTH-type transcriptional regulator -
KTV86_RS12805 (2655933) 2655933..2656643 + 711 WP_000190524.1 DUF3053 domain-containing protein -
KTV86_RS12810 (2656693) 2656693..2657667 - 975 WP_000804675.1 glyoxylate/hydroxypyruvate reductase GhrB -
KTV86_RS12815 (2657886) 2657886..2658548 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(22-143)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 153 a.a.        Molecular weight: 16814.40 Da        Isoelectric Point: 9.8725

>T207744 WP_001272118.1 NZ_CP077760:2653162-2653620 [Salmonella enterica subsp. enterica serovar Gallinarum]
MSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNMPDPIPVIIL
ARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLPQ

Download         Length: 459 bp

>T207744 NZ_CP103503:825901-826311 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10966.60 Da        Isoelectric Point: 4.6811

>AT207744 WP_000965887.1 NZ_CP077760:2652860-2653147 [Salmonella enterica subsp. enterica serovar Gallinarum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVSDD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT207744 NZ_CP103503:825654-825920 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3V9NP38


Antitoxin

Source ID Structure
AlphaFold DB B5RGM5

References