Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 2652860..2653620 | Replicon | chromosome |
Accession | NZ_CP077760 | ||
Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | A0A3V9NP38 |
Locus tag | KTV86_RS12785 | Protein ID | WP_001272118.1 |
Coordinates | 2653162..2653620 (+) | Length | 153 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | B5RGM5 |
Locus tag | KTV86_RS12780 | Protein ID | WP_000965887.1 |
Coordinates | 2652860..2653147 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KTV86_RS12760 (2648265) | 2648265..2649176 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
KTV86_RS12765 (2649186) | 2649186..2651255 | + | 2070 | WP_001291741.1 | glycine--tRNA ligase subunit beta | - |
KTV86_RS12770 (2651645) | 2651645..2652043 | + | 399 | Protein_2491 | IS3 family transposase | - |
KTV86_RS12775 (2652215) | 2652215..2652682 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
KTV86_RS12780 (2652860) | 2652860..2653147 | + | 288 | WP_000965887.1 | DUF1778 domain-containing protein | Antitoxin |
KTV86_RS12785 (2653162) | 2653162..2653620 | + | 459 | WP_001272118.1 | GNAT family N-acetyltransferase | Toxin |
KTV86_RS12790 (2653991) | 2653991..2654530 | - | 540 | WP_000047147.1 | copper-binding periplasmic metallochaperone CueP | - |
KTV86_RS12795 (2654704) | 2654704..2654916 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
KTV86_RS12800 (2655204) | 2655204..2655494 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
KTV86_RS12805 (2655933) | 2655933..2656643 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
KTV86_RS12810 (2656693) | 2656693..2657667 | - | 975 | WP_000804675.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
KTV86_RS12815 (2657886) | 2657886..2658548 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 153 a.a. Molecular weight: 16814.40 Da Isoelectric Point: 9.8725
>T207744 WP_001272118.1 NZ_CP077760:2653162-2653620 [Salmonella enterica subsp. enterica serovar Gallinarum]
MSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNMPDPIPVIIL
ARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLPQ
MSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNMPDPIPVIIL
ARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLPQ
Download Length: 459 bp
>T207744 NZ_CP103503:825901-826311 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10966.60 Da Isoelectric Point: 4.6811
>AT207744 WP_000965887.1 NZ_CP077760:2652860-2653147 [Salmonella enterica subsp. enterica serovar Gallinarum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVSDD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVSDD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT207744 NZ_CP103503:825654-825920 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V9NP38 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | B5RGM5 |