Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1959466..1960247 Replicon chromosome
Accession NZ_CP077760
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag KTV86_RS09580 Protein ID WP_000626100.1
Coordinates 1959466..1959957 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag KTV86_RS09585 Protein ID WP_001110452.1
Coordinates 1959954..1960247 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTV86_RS09545 (1954926) 1954926..1955273 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
KTV86_RS09550 (1955249) 1955249..1956952 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
KTV86_RS09555 (1956989) 1956989..1957564 + 576 WP_001188507.1 transcriptional regulator -
KTV86_RS09565 (1957835) 1957835..1957909 - 75 Protein_1877 helix-turn-helix domain-containing protein -
KTV86_RS09570 (1958289) 1958289..1958366 + 78 Protein_1878 porin family protein -
KTV86_RS09575 (1958466) 1958466..1959218 + 753 WP_223671826.1 non-specific acid phosphatase -
KTV86_RS09580 (1959466) 1959466..1959957 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
KTV86_RS09585 (1959954) 1959954..1960247 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
KTV86_RS09590 (1960564) 1960564..1960785 + 222 WP_001576552.1 hypothetical protein -
KTV86_RS09595 (1961051) 1961051..1961926 + 876 WP_000921676.1 AraC family transcriptional regulator -
KTV86_RS09600 (1961923) 1961923..1962210 + 288 WP_001576551.1 transcriptional regulator RtsB -
KTV86_RS09605 (1962203) 1962203..1962511 - 309 WP_001576549.1 ABC transporter ATP-binding protein -
KTV86_RS09610 (1962510) 1962510..1962758 + 249 Protein_1886 Ig-like domain-containing protein -
KTV86_RS09615 (1962870) 1962870..1963001 + 132 Protein_1887 hypothetical protein -
KTV86_RS09620 (1963291) 1963291..1964196 - 906 WP_001268199.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T207741 WP_000626100.1 NZ_CP077760:c1959957-1959466 [Salmonella enterica subsp. enterica serovar Gallinarum]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T207741 NZ_CP103501:4680-5012 [Klebsiella pneumoniae]
ATGGTATCTCGTTTTGTGCCGGATGCTGGCGACCTTATCTGGATAAATTTTGATCCCGTGGAAGGACATGAGCAAGGAGG
GCATCGCCCCGCAGTCGTGCTGAGTCCGTTTGCATACAACAACAAAACAGGTTTGTTGCTGTGCGTACCTTGCACAACAA
AAGTAAAAGGCTATCCCTTTGAAGTTGAATTGCCAGGAGAACGCGATGGTGTAGCTCTTGCAGATCAAATAACGTGTGTA
GACTGGCGAGCCAGAAAAGTAGAAAAGAAGGGAAAGGTTGCCACCGGAGAATTGTCAGAAATCAGAGCTAAAGCAAAAGC
CTTAATCGGTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT207741 WP_001110452.1 NZ_CP077760:c1960247-1959954 [Salmonella enterica subsp. enterica serovar Gallinarum]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT207741 NZ_CP103501:4435-4680 [Klebsiella pneumoniae]
ATGTCACAGGCAACGTTCAAGAAATGGGGTAACCAGGCAGGAATTCGTTTTCCGGCAGCGGTGATGAAAGCAGCAGCGCT
TAACGTAGATGATACGGTTGATATTGAGGTACAGGAAGGGCGGATTGTACTCATACCAACGAAAGAAAAGACCTATTCAC
TCGATGCCTTATTATCCGGCATCACCGAAGAAAACATGCATAACAAAGCTGACTTCGGCAAACCGACAGGGAAGGAAATG
CTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References