Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1852557..1853073 Replicon chromosome
Accession NZ_CP077760
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag KTV86_RS09005 Protein ID WP_000220582.1
Coordinates 1852557..1852841 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KTV86_RS09010 Protein ID WP_000212724.1
Coordinates 1852831..1853073 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTV86_RS08990 (1847772) 1847772..1849420 + 1649 Protein_1766 alpha,alpha-phosphotrehalase -
KTV86_RS08995 (1849829) 1849829..1851967 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KTV86_RS09000 (1852089) 1852089..1852553 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KTV86_RS09005 (1852557) 1852557..1852841 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTV86_RS09010 (1852831) 1852831..1853073 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KTV86_RS09015 (1853151) 1853151..1855064 - 1914 WP_001212142.1 BglG family transcription antiterminator -
KTV86_RS09020 (1855081) 1855081..1855821 - 741 Protein_1772 KDGP aldolase family protein -
KTV86_RS09025 (1855818) 1855818..1856936 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KTV86_RS09030 (1856920) 1856920..1858053 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T207740 WP_000220582.1 NZ_CP077760:c1852841-1852557 [Salmonella enterica subsp. enterica serovar Gallinarum]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207740 NZ_CP103500:54046-54528 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207740 WP_000212724.1 NZ_CP077760:c1853073-1852831 [Salmonella enterica subsp. enterica serovar Gallinarum]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207740 NZ_CP103500:53792-54058 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References