Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 1811511..1812061 | Replicon | chromosome |
| Accession | NZ_CP077760 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain 07Q015 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | M7RJ32 |
| Locus tag | KTV86_RS08785 | Protein ID | WP_001199743.1 |
| Coordinates | 1811511..1811819 (-) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7RP97 |
| Locus tag | KTV86_RS08790 | Protein ID | WP_001118105.1 |
| Coordinates | 1811822..1812061 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTV86_RS23280 (1807194) | 1807194..1807583 | - | 390 | WP_263300942.1 | fimbria/pilus outer membrane usher protein | - |
| KTV86_RS08760 (1807644) | 1807644..1808069 | - | 426 | Protein_1724 | FimD/PapC N-terminal domain-containing protein | - |
| KTV86_RS08765 (1808086) | 1808086..1808826 | - | 741 | WP_001575372.1 | SEF14/SEF18 fimbria chaperone SefB | - |
| KTV86_RS08770 (1808948) | 1808948..1809445 | - | 498 | WP_001674837.1 | SEF14 fimbria major subunit SefA | - |
| KTV86_RS08775 (1809800) | 1809800..1810933 | + | 1134 | Protein_1727 | IS3 family transposase | - |
| KTV86_RS08780 (1810965) | 1810965..1811105 | - | 141 | Protein_1728 | Arm DNA-binding domain-containing protein | - |
| KTV86_RS08785 (1811511) | 1811511..1811819 | - | 309 | WP_001199743.1 | CcdB family protein | Toxin |
| KTV86_RS08790 (1811822) | 1811822..1812061 | - | 240 | WP_001118105.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| KTV86_RS08795 (1812170) | 1812170..1812418 | - | 249 | WP_000168388.1 | ribbon-helix-helix domain-containing protein | - |
| KTV86_RS08800 (1812609) | 1812609..1813040 | - | 432 | Protein_1732 | helix-turn-helix domain-containing protein | - |
| KTV86_RS08815 (1813797) | 1813797..1814816 | + | 1020 | WP_000152555.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| KTV86_RS08820 (1814844) | 1814844..1815374 | - | 531 | WP_000896758.1 | gluconokinase | - |
| KTV86_RS08825 (1815591) | 1815591..1816622 | + | 1032 | WP_000453347.1 | L-idonate 5-dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 1809892..1812995 | 3103 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11845.67 Da Isoelectric Point: 6.7228
>T207739 WP_001199743.1 NZ_CP077760:c1811819-1811511 [Salmonella enterica subsp. enterica serovar Gallinarum]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
Download Length: 309 bp
>T207739 NZ_CP103499:c5267227-5266844 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8719.90 Da Isoelectric Point: 6.4633
>AT207739 WP_001118105.1 NZ_CP077760:c1812061-1811822 [Salmonella enterica subsp. enterica serovar Gallinarum]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
Download Length: 240 bp
>AT207739 NZ_CP103499:c5267469-5267227 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6C6Z9V9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H9SZK8 |