Detailed information of TA system TA207725

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 925089..926562
• Replicon: chromosome
• Accession: NZ_CP077758
• Organism: Mycoplasmopsis bovis strain RM16

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: FWK06_RS04140
• Protein ID: WP_152028827.1
• Coordinates: 925696..926562 (+)
• Length: 289 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: FWK06_RS04135
• Protein ID: WP_152028826.1
• Coordinates: 925089..925703 (+)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FWK06_RS04110	920730..921611	-	882	WP_226690172.1	variable surface lipoprotein	-
FWK06_RS04115 (FWK06_004075)	922012..922197	-	186	Protein_788	variable surface lipoprotein	-
FWK06_RS04120 (FWK06_004080)	922367..922990	-	624	WP_226690173.1	variable surface lipoprotein	-
FWK06_RS04125	923160..923999	-	840	WP_226690174.1	variable surface lipoprotein	-
FWK06_RS04130 (FWK06_004090)	924155..924907	-	753	WP_226690175.1	variable surface lipoprotein	-
FWK06_RS04135 (FWK06_004095)	925089..925703	+	615	WP_152028826.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FWK06_RS04140 (FWK06_004100)	925696..926562	+	867	WP_152028827.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FWK06_RS04480 (FWK06_004105)	926676..927590	+	915	WP_235732046.1	variable surface lipoprotein	-
FWK06_RS04155 (FWK06_004110)	927633..928466	-	834	WP_226690176.1	variable surface lipoprotein	-
FWK06_RS04160 (FWK06_004115)	928974..929159	-	186	Protein_796	variable surface lipoprotein	-
FWK06_RS04165 (FWK06_004120)	929952..930980	+	1029	WP_080551569.1	IS30-like element ISMbov1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	929862..930980	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 289 a.a.
• Molecular weight: 33522.63 Da
• Isoelectric Point: 6.5024

>T207725 WP_152028827.1 NZ_CP077758:925696-926562 [Mycoplasmopsis bovis]
MNKNKLISLCHKIADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKAEELTNNDEI

Nucleotide

• Length: 867 bp

>T207725 NZ_CP103494:c2730814-2730711 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24085.79 Da
• Isoelectric Point: 9.7565

>AT207725 WP_152028826.1 NZ_CP077758:925089-925703 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMIAKGVLIRKAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

>AT207725 NZ_CP103494:2730698-2730907 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAGCCGC