Detailed information of TA system TA207721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2652356..2652885
• Replicon: chromosome
• Accession: NZ_CP077757
• Organism: Staphylococcus aureus strain WHC07

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KTR68_RS13020
• Protein ID: WP_000621175.1
• Coordinates: 2652523..2652885 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: KTR68_RS13015
• Protein ID: WP_000948331.1
• Coordinates: 2652356..2652526 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTR68_RS12985	2647392..2647952	+	561	WP_001092410.1	K(+)-transporting ATPase subunit C	-
KTR68_RS12990	2648161..2648640	+	480	WP_031590204.1	hypothetical protein	-
KTR68_RS12995	2648633..2650216	+	1584	WP_001294626.1	PH domain-containing protein	-
KTR68_RS13000	2650203..2650694	+	492	WP_072353916.1	PH domain-containing protein	-
KTR68_RS13005	2650698..2651057	+	360	WP_000581197.1	holo-ACP synthase	-
KTR68_RS13010	2651123..2652271	+	1149	WP_001281154.1	alanine racemase	-
KTR68_RS13015	2652356..2652526	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
KTR68_RS13020	2652523..2652885	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KTR68_RS13025	2653235..2654236	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
KTR68_RS13030	2654355..2654681	+	327	WP_001052491.1	anti-sigma factor antagonist	-
KTR68_RS13035	2654683..2655162	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
KTR68_RS13040	2655137..2655907	+	771	WP_001041102.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T207721 WP_000621175.1 NZ_CP077757:2652523-2652885 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T207721 NZ_CP103494:c1122092-1121874 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACTCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT207721 WP_000948331.1 NZ_CP077757:2652356-2652526 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT207721 NZ_CP103494:c1122494-1122120 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1