Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2632631..2633145 Replicon chromosome
Accession NZ_CP077757
Organism Staphylococcus aureus strain WHC07

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KTR68_RS12930 Protein ID WP_000581793.1
Coordinates 2632936..2633145 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KTR68_RS12925 Protein ID WP_000138932.1
Coordinates 2632631..2632924 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR68_RS12905 2628093..2628734 + 642 WP_000483155.1 thiamine phosphate synthase -
KTR68_RS12910 2628820..2629692 + 873 WP_000725802.1 membrane protein insertase YidC -
KTR68_RS12915 2630306..2630953 - 648 WP_031590210.1 HD domain-containing protein -
KTR68_RS12920 2630981..2632465 - 1485 WP_000571549.1 cardiolipin synthase -
KTR68_RS12925 2632631..2632924 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KTR68_RS12930 2632936..2633145 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KTR68_RS12935 2633273..2633410 + 138 WP_000828354.1 Lmo0850 family protein -
KTR68_RS12940 2633673..2634875 - 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
KTR68_RS12945 2635193..2636263 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
KTR68_RS12950 2636278..2637636 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T207720 WP_000581793.1 NZ_CP077757:2632936-2633145 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T207720 NZ_CP103494:c342534-342232 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT207720 WP_000138932.1 NZ_CP077757:2632631-2632924 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT207720 NZ_CP103494:c342225-341938 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References