Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1098243..1098720 Replicon chromosome
Accession NZ_CP077757
Organism Staphylococcus aureus strain WHC07

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KTR68_RS05420 Protein ID WP_000052076.1
Coordinates 1098532..1098720 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KTR68_RS05415 Protein ID WP_001059690.1
Coordinates 1098243..1098503 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR68_RS05380 1093635..1094351 - 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -
KTR68_RS05385 1094499..1094921 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KTR68_RS05390 1095320..1095814 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KTR68_RS05395 1095970..1096587 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
KTR68_RS05400 1096660..1097241 - 582 WP_001140697.1 histidine phosphatase family protein -
KTR68_RS05405 1097466..1097702 + 237 WP_000368687.1 hypothetical protein -
KTR68_RS05410 1097699..1097902 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KTR68_RS05415 1098243..1098503 + 261 WP_001059690.1 hypothetical protein Antitoxin
KTR68_RS05420 1098532..1098720 + 189 WP_000052076.1 hypothetical protein Toxin
KTR68_RS05425 1098908..1099477 + 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
KTR68_RS05430 1099565..1099849 + 285 WP_031590186.1 hypothetical protein -
KTR68_RS05435 1099911..1100129 + 219 WP_000005887.1 hypothetical protein -
KTR68_RS05440 1100625..1100825 - 201 WP_001059082.1 cold-shock protein -
KTR68_RS05445 1101182..1101868 - 687 WP_001641381.1 thermonuclease family protein -
KTR68_RS05450 1102209..1102685 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T207711 WP_000052076.1 NZ_CP077757:1098532-1098720 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T207711 NZ_CP103487:791342-791752 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT207711 WP_001059690.1 NZ_CP077757:1098243-1098503 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT207711 NZ_CP103487:791095-791361 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References