Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 207612..208201 Replicon chromosome
Accession NC_004307
Organism Bifidobacterium longum NCC2705

Toxin (Protein)


Gene name PumA Uniprot ID B3DQN5
Locus tag BL_RS00890 Protein ID WP_010080907.1
Coordinates 207893..208201 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag BL_RS00885 Protein ID WP_007057517.1
Coordinates 207612..207896 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL_RS00860 203758..205296 + 1539 WP_007054402.1 UDP-N-acetylmuramate--L-alanine ligase -
BL_RS00865 205431..206360 + 930 WP_014484721.1 FtsQ-type POTRA domain-containing protein -
BL_RS00875 207183..207404 - 222 WP_077422270.1 holin -
BL_RS00885 207612..207896 - 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
BL_RS00890 207893..208201 - 309 WP_010080907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BL_RS00895 208233..208529 - 297 WP_007057519.1 hypothetical protein -
BL_RS00900 208688..209176 + 489 WP_164928208.1 D-tyrosyl-tRNA(Tyr) deacylase -
BL_RS00905 209337..212456 + 3120 WP_011067986.1 alpha-mannosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-94)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11610.38 Da        Isoelectric Point: 10.3171

>T20771 WP_010080907.1 NC_004307:c208201-207893 [Bifidobacterium longum NCC2705]
MEIKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDK
STQQTDIRQAHDILNDYKEQRQ

Download         Length: 309 bp

>T20771 NC_004307:c208201-207893 [Bifidobacterium longum NCC2705]
ATGGAAATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGC
CCGGCTCGATGCCTGCAAGCTCGCAGGCAGGCCATTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACACCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT20771 WP_007057517.1 NC_004307:c207896-207612 [Bifidobacterium longum NCC2705]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp

>AT20771 NC_004307:c207896-207612 [Bifidobacterium longum NCC2705]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAATGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGGCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAAACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0U788

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References