Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2689513..2690042 Replicon chromosome
Accession NZ_CP077755
Organism Staphylococcus aureus strain WHC09

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KTR65_RS13230 Protein ID WP_000621175.1
Coordinates 2689680..2690042 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KTR65_RS13225 Protein ID WP_000948331.1
Coordinates 2689513..2689683 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR65_RS13195 2684549..2685109 + 561 WP_001092410.1 K(+)-transporting ATPase subunit C -
KTR65_RS13200 2685318..2685797 + 480 WP_031590204.1 hypothetical protein -
KTR65_RS13205 2685790..2687373 + 1584 WP_001294626.1 PH domain-containing protein -
KTR65_RS13210 2687360..2687851 + 492 WP_165619041.1 PH domain-containing protein -
KTR65_RS13215 2687855..2688214 + 360 WP_000581197.1 holo-ACP synthase -
KTR65_RS13220 2688280..2689428 + 1149 WP_001281154.1 alanine racemase -
KTR65_RS13225 2689513..2689683 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KTR65_RS13230 2689680..2690042 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KTR65_RS13235 2690392..2691393 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
KTR65_RS13240 2691512..2691838 + 327 WP_001052491.1 anti-sigma factor antagonist -
KTR65_RS13245 2691840..2692319 + 480 WP_001190829.1 anti-sigma B factor RsbW -
KTR65_RS13250 2692294..2693064 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T207707 WP_000621175.1 NZ_CP077755:2689680-2690042 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T207707 NZ_CP103480:55975-56124 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT207707 WP_000948331.1 NZ_CP077755:2689513-2689683 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT207707 NZ_CP103480:c55931-55870 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References