Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2669788..2670302 Replicon chromosome
Accession NZ_CP077755
Organism Staphylococcus aureus strain WHC09

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KTR65_RS13140 Protein ID WP_000581793.1
Coordinates 2670093..2670302 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KTR65_RS13135 Protein ID WP_000138932.1
Coordinates 2669788..2670081 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR65_RS13115 2665250..2665891 + 642 WP_000483155.1 thiamine phosphate synthase -
KTR65_RS13120 2665977..2666849 + 873 WP_000725802.1 membrane protein insertase YidC -
KTR65_RS13125 2667463..2668110 - 648 WP_031590210.1 HD domain-containing protein -
KTR65_RS13130 2668138..2669622 - 1485 WP_000571549.1 cardiolipin synthase -
KTR65_RS13135 2669788..2670081 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KTR65_RS13140 2670093..2670302 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KTR65_RS13145 2670430..2670567 + 138 WP_000828354.1 Lmo0850 family protein -
KTR65_RS13150 2670830..2672032 - 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
KTR65_RS13155 2672350..2673420 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
KTR65_RS13160 2673435..2674793 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T207706 WP_000581793.1 NZ_CP077755:2670093-2670302 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T207706 NZ_CP103479:c4686875-4686702 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT207706 WP_000138932.1 NZ_CP077755:2669788-2670081 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT207706 NZ_CP103479:c4687199-4686903 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References