207697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1089626..1090103 Replicon chromosome
Accession NZ_CP077755
Organism Staphylococcus aureus strain WHC09

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KTR65_RS05375 Protein ID WP_000052076.1
Coordinates 1089915..1090103 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KTR65_RS05370 Protein ID WP_001059690.1
Coordinates 1089626..1089886 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR65_RS05335 1085018..1085734 - 717 WP_031589686.1 type I 3-dehydroquinate dehydratase -
KTR65_RS05340 1085882..1086304 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KTR65_RS05345 1086703..1087197 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KTR65_RS05350 1087353..1087970 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
KTR65_RS05355 1088043..1088624 - 582 WP_001140697.1 histidine phosphatase family protein -
KTR65_RS05360 1088849..1089085 + 237 WP_000368687.1 hypothetical protein -
KTR65_RS05365 1089082..1089285 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KTR65_RS05370 1089626..1089886 + 261 WP_001059690.1 hypothetical protein Antitoxin
KTR65_RS05375 1089915..1090103 + 189 WP_000052076.1 hypothetical protein Toxin
KTR65_RS05380 1090291..1090860 + 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
KTR65_RS05385 1090948..1091232 + 285 WP_031590186.1 hypothetical protein -
KTR65_RS05390 1091294..1091512 + 219 WP_000005887.1 hypothetical protein -
KTR65_RS05395 1092008..1092208 - 201 WP_001059082.1 cold-shock protein -
KTR65_RS05400 1092565..1093251 - 687 WP_001641381.1 thermonuclease family protein -
KTR65_RS05405 1093592..1094068 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T207697 WP_000052076.1 NZ_CP077755:1089915-1090103 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T207697 NZ_CP103479:3418298-3418684 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT207697 WP_001059690.1 NZ_CP077755:1089626-1089886 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT207697 NZ_CP103479:3418674-3419003 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References