Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2243233..2243747 Replicon chromosome
Accession NZ_CP077741
Organism Staphylococcus aureus strain NL1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KTE72_RS11180 Protein ID WP_000581792.1
Coordinates 2243233..2243442 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KTE72_RS11185 Protein ID WP_000138932.1
Coordinates 2243454..2243747 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTE72_RS11160 (KTE72_11080) 2238744..2240099 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KTE72_RS11165 (KTE72_11085) 2240114..2241184 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KTE72_RS11170 (KTE72_11090) 2241502..2242704 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KTE72_RS11175 (KTE72_11095) 2242968..2243105 - 138 WP_000828354.1 Lmo0850 family protein -
KTE72_RS11180 (KTE72_11100) 2243233..2243442 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KTE72_RS11185 (KTE72_11105) 2243454..2243747 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KTE72_RS11190 (KTE72_11110) 2243913..2245397 + 1485 WP_000571550.1 cardiolipin synthase -
KTE72_RS11195 (KTE72_11115) 2245425..2246072 + 648 WP_001187614.1 HD domain-containing protein -
KTE72_RS11200 2246629..2246691 + 63 Protein_2168 hypothetical protein -
KTE72_RS11205 (KTE72_11125) 2246669..2247984 - 1316 Protein_2169 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T207689 WP_000581792.1 NZ_CP077741:c2243442-2243233 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T207689 NZ_CP103479:1072402-1072809 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT207689 WP_000138932.1 NZ_CP077741:c2243747-2243454 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT207689 NZ_CP103479:1072155-1072421 [Escherichia coli]
ATGGATATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References