Detailed information of TA system TA207688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2223496..2224025
• Replicon: chromosome
• Accession: NZ_CP077741
• Organism: Staphylococcus aureus strain NL1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KTE72_RS11090
• Protein ID: WP_000621175.1
• Coordinates: 2223496..2223858 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: KTE72_RS11095
• Protein ID: WP_000948331.1
• Coordinates: 2223855..2224025 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTE72_RS11070 (KTE72_10990)	2220474..2221244	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
KTE72_RS11075 (KTE72_10995)	2221219..2221698	-	480	WP_031863950.1	anti-sigma B factor RsbW	-
KTE72_RS11080 (KTE72_11000)	2221700..2222026	-	327	WP_001052491.1	anti-sigma factor antagonist	-
KTE72_RS11085 (KTE72_11005)	2222145..2223146	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
KTE72_RS11090 (KTE72_11010)	2223496..2223858	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KTE72_RS11095 (KTE72_11015)	2223855..2224025	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
KTE72_RS11100 (KTE72_11020)	2224110..2225258	-	1149	WP_001281139.1	alanine racemase	-
KTE72_RS11105 (KTE72_11025)	2225324..2225683	-	360	WP_000581197.1	holo-ACP synthase	-
KTE72_RS11110 (KTE72_11030)	2225687..2226178	-	492	WP_001286980.1	PH domain-containing protein	-
KTE72_RS11115 (KTE72_11035)	2226171..2227748	-	1578	WP_001294650.1	PH domain-containing protein	-
KTE72_RS11120 (KTE72_11040)	2227741..2228220	-	480	WP_001287081.1	hypothetical protein	-
KTE72_RS11125 (KTE72_11045)	2228429..2228989	-	561	WP_001092419.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T207688 WP_000621175.1 NZ_CP077741:c2223858-2223496 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T207688 NZ_CP103479:c901176-900799 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT207688 WP_000948331.1 NZ_CP077741:c2224025-2223855 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT207688 NZ_CP103479:c901633-901253 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1