Detailed information of TA system TA207686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 921551..922027
• Replicon: chromosome
• Accession: NZ_CP077741
• Organism: Staphylococcus aureus strain NL1

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KTE72_RS04425
• Protein ID: WP_000052076.1
• Coordinates: 921551..921739 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KTE72_RS04430
• Protein ID: WP_031863940.1
• Coordinates: 921767..922027 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTE72_RS04395 (KTE72_04365)	917580..918062	+	483	WP_000824489.1	hypothetical protein	-
KTE72_RS04400 (KTE72_04370)	918403..919089	+	687	WP_001574556.1	thermonuclease family protein	-
KTE72_RS04405 (KTE72_04375)	919446..919646	+	201	WP_001059082.1	cold-shock protein	-
KTE72_RS04410 (KTE72_04380)	920143..920361	-	219	WP_000005881.1	hypothetical protein	-
KTE72_RS04415 (KTE72_04385)	920422..920706	-	285	WP_001004403.1	hypothetical protein	-
KTE72_RS04420 (KTE72_04390)	920794..921363	-	570	WP_001106655.1	lipoprotein N-acylation protein LnsA	-
KTE72_RS04425 (KTE72_04395)	921551..921739	-	189	WP_000052076.1	hypothetical protein	Toxin
KTE72_RS04430 (KTE72_04400)	921767..922027	-	261	WP_031863940.1	hypothetical protein	Antitoxin
KTE72_RS04435 (KTE72_04405)	922369..922572	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KTE72_RS04440 (KTE72_04410)	922569..922805	-	237	WP_000368687.1	hypothetical protein	-
KTE72_RS04445 (KTE72_04415)	923030..923611	+	582	WP_001140696.1	histidine phosphatase family protein	-
KTE72_RS04450 (KTE72_04420)	923684..924301	-	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
KTE72_RS04455 (KTE72_04425)	924450..924944	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KTE72_RS04460 (KTE72_04430)	925343..925765	-	423	WP_000974452.1	organic hydroperoxide resistance protein	-
KTE72_RS04465 (KTE72_04435)	925913..926629	+	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T207686 WP_000052076.1 NZ_CP077741:c921739-921551 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T207686 NZ_CP103479:c71385-71008 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATGACATTAGCCAGGGGAAGTATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9913.06 Da
• Isoelectric Point: 4.0624

>AT207686 WP_031863940.1 NZ_CP077741:c922027-921767 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKSWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT207686 NZ_CP103479:c71842-71474 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GTCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18