Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 369006..369794 Replicon chromosome
Accession NZ_CP077741
Organism Staphylococcus aureus strain NL1

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag KTE72_RS01585 Protein ID WP_000525004.1
Coordinates 369006..369467 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag KTE72_RS01590 Protein ID WP_000333630.1
Coordinates 369480..369794 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTE72_RS01560 (KTE72_01545) 364058..365992 + 1935 Protein_310 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
KTE72_RS01565 (KTE72_01550) 366086..367291 - 1206 WP_031794994.1 tyrosine-type recombinase/integrase -
KTE72_RS01570 (KTE72_01555) 367417..368031 + 615 WP_000191464.1 hypothetical protein -
KTE72_RS01575 (KTE72_01560) 368028..368174 - 147 WP_001795334.1 hypothetical protein -
KTE72_RS01580 (KTE72_01565) 368404..368988 - 585 WP_000825948.1 hypothetical protein -
KTE72_RS01585 (KTE72_01570) 369006..369467 - 462 WP_000525004.1 hypothetical protein Toxin
KTE72_RS01590 (KTE72_01575) 369480..369794 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
KTE72_RS01595 (KTE72_01580) 369946..370182 + 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
KTE72_RS01600 (KTE72_01585) 370196..370972 + 777 WP_001148544.1 Rha family transcriptional regulator -
KTE72_RS01605 (KTE72_01590) 371001..371150 + 150 WP_000771849.1 hypothetical protein -
KTE72_RS01610 (KTE72_01595) 371191..371403 - 213 WP_000362644.1 hypothetical protein -
KTE72_RS01615 (KTE72_01600) 371473..371670 + 198 WP_001148860.1 hypothetical protein -
KTE72_RS01620 (KTE72_01605) 371657..372007 - 351 WP_031795353.1 DUF2513 domain-containing protein -
KTE72_RS01625 (KTE72_01610) 372103..372246 + 144 WP_000939498.1 hypothetical protein -
KTE72_RS01630 (KTE72_01615) 372236..372445 - 210 WP_000642492.1 hypothetical protein -
KTE72_RS01635 (KTE72_01620) 372501..372746 + 246 WP_001025401.1 DUF2829 domain-containing protein -
KTE72_RS01640 (KTE72_01625) 372715..373080 - 366 WP_031795354.1 hypothetical protein -
KTE72_RS01645 (KTE72_01630) 373135..373350 + 216 WP_001097552.1 hypothetical protein -
KTE72_RS01650 (KTE72_01635) 373375..373638 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
KTE72_RS01655 (KTE72_01640) 373651..373812 + 162 WP_001285948.1 DUF1270 domain-containing protein -
KTE72_RS01660 (KTE72_01645) 373891..374214 + 324 WP_000174994.1 hypothetical protein -
KTE72_RS01665 (KTE72_01650) 374229..374591 + 363 WP_000985976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 366086..412432 46346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T207682 WP_000525004.1 NZ_CP077741:c369467-369006 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T207682 NZ_CP103469:c63437-63057 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
CCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTACTGTCGCCGCCACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT207682 WP_000333630.1 NZ_CP077741:c369794-369480 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT207682 NZ_CP103469:c63658-63437 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References