Detailed information of TA system TA207676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2015706..2016482
• Replicon: chromosome
• Accession: NZ_CP077738
• Organism: Staphylococcus aureus strain UMCG578

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KTE14_RS09820
• Protein ID: WP_000031108.1
• Coordinates: 2015706..2015858 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KTE14_RS09825
• Protein ID: WP_001251224.1
• Coordinates: 2015883..2016482 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTE14_RS09805 (KTE14_09740)	2011911..2012732	+	822	WP_000669380.1	RluA family pseudouridine synthase	-
KTE14_RS09810 (KTE14_09745)	2013187..2014572	-	1386	WP_000116238.1	class II fumarate hydratase	-
KTE14_RS09815 (KTE14_09750)	2014768..2015163	-	396	WP_000901018.1	hypothetical protein	-
KTE14_RS09820 (KTE14_09755)	2015706..2015858	-	153	WP_000031108.1	SAS053 family protein	Toxin
KTE14_RS09825 (KTE14_09760)	2015883..2016482	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KTE14_RS09830 (KTE14_09765)	2016641..2017111	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KTE14_RS09835 (KTE14_09770)	2017116..2018243	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KTE14_RS09840 (KTE14_09775)	2018394..2019116	-	723	WP_031774878.1	amino acid ABC transporter ATP-binding protein	-
KTE14_RS09845 (KTE14_09780)	2019109..2020566	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T207676 WP_000031108.1 NZ_CP077738:c2015858-2015706 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T207676 NZ_CP103468:c4232462-4232148 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT207676 WP_001251224.1 NZ_CP077738:c2016482-2015883 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT207676 NZ_CP103468:c4232698-4232465 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4