Detailed information of TA system TA207675

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 925494..925970
• Replicon: chromosome
• Accession: NZ_CP077738
• Organism: Staphylococcus aureus strain UMCG578

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KTE14_RS04445
• Protein ID: WP_000052076.1
• Coordinates: 925494..925682 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KTE14_RS04450
• Protein ID: WP_031863940.1
• Coordinates: 925710..925970 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTE14_RS04415 (KTE14_04385)	921523..922005	+	483	WP_000824489.1	hypothetical protein	-
KTE14_RS04420 (KTE14_04390)	922346..923032	+	687	WP_001574556.1	thermonuclease family protein	-
KTE14_RS04425 (KTE14_04395)	923389..923589	+	201	WP_001059082.1	cold-shock protein	-
KTE14_RS04430 (KTE14_04400)	924086..924304	-	219	WP_000005881.1	hypothetical protein	-
KTE14_RS04435 (KTE14_04405)	924365..924649	-	285	WP_001004403.1	hypothetical protein	-
KTE14_RS04440 (KTE14_04410)	924737..925306	-	570	WP_001106655.1	lipoprotein N-acylation protein LnsA	-
KTE14_RS04445 (KTE14_04415)	925494..925682	-	189	WP_000052076.1	hypothetical protein	Toxin
KTE14_RS04450 (KTE14_04420)	925710..925970	-	261	WP_031863940.1	hypothetical protein	Antitoxin
KTE14_RS04455 (KTE14_04425)	926312..926515	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KTE14_RS04460 (KTE14_04430)	926512..926748	-	237	WP_000368687.1	hypothetical protein	-
KTE14_RS04465 (KTE14_04435)	926973..927554	+	582	WP_001140696.1	histidine phosphatase family protein	-
KTE14_RS04470 (KTE14_04440)	927627..928244	-	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
KTE14_RS04475 (KTE14_04445)	928393..928887	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KTE14_RS04480 (KTE14_04450)	929286..929708	-	423	WP_000974452.1	organic hydroperoxide resistance protein	-
KTE14_RS04485 (KTE14_04455)	929856..930572	+	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin YafO (27-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T207675 WP_000052076.1 NZ_CP077738:c925682-925494 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T207675 NZ_CP103468:c4008574-4008176 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9913.06 Da
• Isoelectric Point: 4.0624

>AT207675 WP_031863940.1 NZ_CP077738:c925970-925710 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKSWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT207675 NZ_CP103468:c4008870-4008577 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18