207674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 367138..367926 Replicon chromosome
Accession NZ_CP077738
Organism Staphylococcus aureus strain UMCG578

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag KTE14_RS01585 Protein ID WP_000525004.1
Coordinates 367138..367599 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag KTE14_RS01590 Protein ID WP_000333630.1
Coordinates 367612..367926 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTE14_RS01560 (KTE14_01545) 362190..364124 + 1935 Protein_310 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
KTE14_RS01565 (KTE14_01550) 364218..365423 - 1206 WP_031794994.1 tyrosine-type recombinase/integrase -
KTE14_RS01570 (KTE14_01555) 365549..366163 + 615 WP_000191464.1 hypothetical protein -
KTE14_RS01575 (KTE14_01560) 366160..366306 - 147 WP_001795334.1 hypothetical protein -
KTE14_RS01580 (KTE14_01565) 366536..367120 - 585 WP_000825948.1 hypothetical protein -
KTE14_RS01585 (KTE14_01570) 367138..367599 - 462 WP_000525004.1 hypothetical protein Toxin
KTE14_RS01590 (KTE14_01575) 367612..367926 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
KTE14_RS01595 (KTE14_01580) 368078..368314 + 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
KTE14_RS01600 (KTE14_01585) 368328..369104 + 777 WP_001148544.1 Rha family transcriptional regulator -
KTE14_RS01605 (KTE14_01590) 369133..369282 + 150 WP_000771849.1 hypothetical protein -
KTE14_RS01610 (KTE14_01595) 369323..369535 - 213 WP_000362644.1 hypothetical protein -
KTE14_RS01615 (KTE14_01600) 369605..369802 + 198 WP_001148860.1 hypothetical protein -
KTE14_RS01620 (KTE14_01605) 369789..370169 - 381 WP_000773059.1 DUF2513 domain-containing protein -
KTE14_RS01625 (KTE14_01610) 370236..370379 + 144 WP_000939498.1 hypothetical protein -
KTE14_RS01630 (KTE14_01615) 370369..370578 - 210 WP_000642492.1 hypothetical protein -
KTE14_RS01635 (KTE14_01620) 370634..370849 + 216 WP_001097552.1 hypothetical protein -
KTE14_RS01640 (KTE14_01625) 370874..371137 + 264 WP_016187436.1 helix-turn-helix domain-containing protein -
KTE14_RS01645 (KTE14_01630) 371150..371311 + 162 WP_001285948.1 DUF1270 domain-containing protein -
KTE14_RS01650 (KTE14_01635) 371390..371713 + 324 WP_000174994.1 hypothetical protein -
KTE14_RS01655 (KTE14_01640) 371728..372090 + 363 WP_000985976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 364218..411966 47748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T207674 WP_000525004.1 NZ_CP077738:c367599-367138 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T207674 NZ_CP103468:3797106-3797324 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT207674 WP_000333630.1 NZ_CP077738:c367926-367612 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT207674 NZ_CP103468:3796706-3797080 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References