Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 930824..931398 Replicon chromosome
Accession NZ_CP077723
Organism Pasteurella multocida strain PMWSG-4

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KSF84_RS04445 Protein ID WP_061406134.1
Coordinates 931114..931398 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KSF84_RS04440 Protein ID WP_061406133.1
Coordinates 930824..931117 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSF84_RS04420 (KSF84_04420) 925983..927074 - 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -
KSF84_RS04425 (KSF84_04425) 927424..929214 + 1791 WP_061406132.1 PTS ascorbate-specific subunit IIBC -
KSF84_RS04430 (KSF84_04430) 929259..929726 + 468 WP_064661066.1 PTS sugar transporter subunit IIA -
KSF84_RS04435 (KSF84_04435) 929744..930421 + 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
KSF84_RS04440 (KSF84_04440) 930824..931117 - 294 WP_061406133.1 putative addiction module antidote protein Antitoxin
KSF84_RS04445 (KSF84_04445) 931114..931398 - 285 WP_061406134.1 hypothetical protein Toxin
KSF84_RS04455 (KSF84_04455) 932677..933012 - 336 WP_223848039.1 DUF3418 domain-containing protein -
KSF84_RS04460 (KSF84_04460) 933240..933731 + 492 WP_256447825.1 NERD domain-containing protein -
KSF84_RS04465 (KSF84_04465) 934016..935605 + 1590 WP_081106270.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T207671 WP_061406134.1 NZ_CP077723:c931398-931114 [Pasteurella multocida]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T207671 NZ_CP103468:3066074-3066568 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10947.88 Da        Isoelectric Point: 8.9149

>AT207671 WP_061406133.1 NZ_CP077723:c931117-930824 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp

>AT207671 NZ_CP103468:3065784-3066077 [Escherichia coli]
ATGGCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATAGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCTCCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References