Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 1943346..1944325 Replicon chromosome
Accession NZ_CP077717
Organism Saccharolobus shibatae B12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5U23_RS10220 Protein ID WP_218258149.1
Coordinates 1943711..1944325 (+) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5U23_RS10215 Protein ID WP_218260273.1
Coordinates 1943346..1943693 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5U23_RS10190 (J5U23_02113) 1938639..1940138 + 1500 WP_218266084.1 thiamine pyrophosphate-binding protein -
J5U23_RS10195 (J5U23_02114) 1940692..1941670 - 979 Protein_1994 transposase -
J5U23_RS10200 (J5U23_02115) 1942144..1942575 + 432 WP_218260690.1 universal stress protein -
J5U23_RS10205 (J5U23_02116) 1942568..1942951 - 384 WP_218266085.1 metal-sulfur cluster assembly factor -
J5U23_RS10210 (J5U23_02117) 1942999..1943274 + 276 WP_240780783.1 hypothetical protein -
J5U23_RS10215 (J5U23_02118) 1943346..1943693 + 348 WP_218260273.1 DUF488 domain-containing protein Antitoxin
J5U23_RS10220 (J5U23_02119) 1943711..1944325 + 615 WP_218258149.1 helix-turn-helix domain-containing protein Toxin
J5U23_RS10225 (J5U23_02120) 1944370..1944645 - 276 WP_218266086.1 hypothetical protein -
J5U23_RS10230 (J5U23_02121) 1944770..1945297 + 528 WP_218266087.1 hemerythrin domain-containing protein -
J5U23_RS10235 (J5U23_02122) 1945402..1946148 + 747 WP_218266088.1 plastocyanin/azurin family copper-binding protein -
J5U23_RS10240 (J5U23_02123) 1946152..1946475 + 324 WP_218266089.1 hypothetical protein -
J5U23_RS10245 1946456..1946683 - 228 WP_218266090.1 hypothetical protein -
J5U23_RS10250 (J5U23_02124) 1946931..1947530 + 600 WP_218258155.1 DUF2249 domain-containing protein -
J5U23_RS10255 1947800..1949059 + 1260 Protein_2006 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23212.23 Da        Isoelectric Point: 9.2823

>T207670 WP_218258149.1 NZ_CP077717:1943711-1944325 [Saccharolobus shibatae B12]
MLKSPFEVTILIEEHPCEVMRIISSTGLKATVDNVKLGDNATDHIVLFEKEVQKDDLIKLKSHSTKVLKLNDSKVWVRTN
GCSVCKILYTSNVVVEKIKVVKERTLLYTLLVPNTIAFKEFLANLTSQGIKFTVLNTSEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISAPTLEEIMRRALRKVVKYYLDKVG

Download         Length: 615 bp

>T207670 NZ_CP103468:2905881-2905988 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13720.03 Da        Isoelectric Point: 10.0168

>AT207670 WP_218260273.1 NZ_CP077717:1943346-1943693 [Saccharolobus shibatae B12]
MIKIKRVYDPIEKDDGIRILVDRLWPRGIGKNKVDLWLKDIAPSDELRRWYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKQ

Download         Length: 348 bp

>AT207670 NZ_CP103468:c2905831-2905774 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References