Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 1553506..1554112 Replicon chromosome
Accession NZ_CP077717
Organism Saccharolobus shibatae B12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5U23_RS08375 Protein ID WP_218257805.1
Coordinates 1553506..1553898 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5U23_RS08380 Protein ID WP_218265848.1
Coordinates 1553888..1554112 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5U23_RS08350 (J5U23_01695) 1549130..1549531 + 402 WP_218257797.1 hypothetical protein -
J5U23_RS15795 (J5U23_01696) 1550463..1550615 - 153 WP_244988755.1 hypothetical protein -
J5U23_RS08360 (J5U23_01697) 1550834..1551412 - 579 WP_244988756.1 hypothetical protein -
J5U23_RS15800 1551375..1551677 - 303 WP_244988757.1 hypothetical protein -
J5U23_RS15805 (J5U23_01698) 1551853..1552182 + 330 WP_244988758.1 hypothetical protein -
J5U23_RS15810 (J5U23_01699) 1552286..1552756 + 471 WP_244988759.1 ATP-binding protein -
J5U23_RS15815 (J5U23_01700) 1552819..1553007 + 189 WP_244988760.1 hypothetical protein -
J5U23_RS15820 (J5U23_01701) 1553199..1553339 + 141 WP_244988761.1 hypothetical protein -
J5U23_RS16005 (J5U23_01702) 1553332..1553466 + 135 WP_280638372.1 hypothetical protein -
J5U23_RS08375 (J5U23_01703) 1553506..1553898 - 393 WP_218257805.1 type II toxin-antitoxin system VapC family toxin Toxin
J5U23_RS08380 (J5U23_01704) 1553888..1554112 - 225 WP_218265848.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J5U23_RS08385 1554231..1554481 - 251 Protein_1625 IS6 family transposase -
J5U23_RS08390 (J5U23_01707) 1555132..1555449 - 318 WP_218265849.1 clan AA aspartic protease -
J5U23_RS08395 (J5U23_01708) 1555450..1556406 - 957 WP_218265850.1 putative CRISPR-associated protein -
J5U23_RS15825 (J5U23_01709) 1557100..1557273 - 174 WP_244988762.1 hypothetical protein -
J5U23_RS15830 (J5U23_01710) 1557454..1557741 - 288 WP_244988763.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-56)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15128.84 Da        Isoelectric Point: 9.0292

>T207669 WP_218257805.1 NZ_CP077717:c1553898-1553506 [Saccharolobus shibatae B12]
MKDKEFLLDASALYSLLDYVDKVDVKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVVEDPPLEGV
MRIAIERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T207669 NZ_CP103468:2905346-2905453 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8784.10 Da        Isoelectric Point: 5.3565

>AT207669 WP_218265848.1 NZ_CP077717:c1554112-1553888 [Saccharolobus shibatae B12]
MSDVISVRVKKELKKKAEELGINIREVVEKALEEAIKEKEKEELKDTAKKIKELMRDVSEDDWVRTVRESRDER

Download         Length: 225 bp

>AT207669 NZ_CP103468:c2905293-2905232 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References