Detailed information of TA system TA207667

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1230960..1231572
• Replicon: chromosome
• Accession: NZ_CP077717
• Organism: Saccharolobus shibatae B12

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J5U23_RS06840
• Protein ID: WP_218261487.1
• Coordinates: 1231180..1231572 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J5U23_RS06835
• Protein ID: WP_218260056.1
• Coordinates: 1230960..1231193 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5U23_RS06810 (J5U23_01338)	1227298..1227504	+	207	WP_218267335.1	hypothetical protein	-
J5U23_RS06815 (J5U23_01339)	1227766..1227960	-	195	WP_218267336.1	hypothetical protein	-
J5U23_RS06820 (J5U23_01340)	1228173..1228871	+	699	WP_218267337.1	TIGR00266 family protein	-
J5U23_RS15715	1229174..1229432	+	259	Protein_1302	hypothetical protein	-
J5U23_RS06830 (J5U23_01342)	1229495..1230445	-	951	WP_218267339.1	IS110 family transposase	-
J5U23_RS06835 (J5U23_01343)	1230960..1231193	+	234	WP_218260056.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
J5U23_RS06840 (J5U23_01344)	1231180..1231572	+	393	WP_218261487.1	PIN domain-containing protein	Toxin
J5U23_RS06845 (J5U23_01346)	1232122..1232643	+	522	WP_218260058.1	hypothetical protein	-
J5U23_RS06850 (J5U23_01347)	1232966..1233394	+	429	WP_218267340.1	HEPN domain-containing protein	-
J5U23_RS06855 (J5U23_01348)	1233357..1233797	+	441	WP_218260060.1	nucleotidyltransferase domain-containing protein	-
J5U23_RS06860	1233914..1233997	-	84	Protein_1309	transposase	-
J5U23_RS06865 (J5U23_01349)	1234212..1234397	-	186	WP_244988865.1	hypothetical protein	-
J5U23_RS06870 (J5U23_01350)	1234582..1234812	+	231	WP_218267341.1	CopG family transcriptional regulator	-
J5U23_RS06875 (J5U23_01351)	1234809..1235198	+	390	WP_218267342.1	type II toxin-antitoxin system VapC family toxin	-
J5U23_RS06880 (J5U23_01352)	1235290..1235526	+	237	WP_218260062.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
J5U23_RS06885 (J5U23_01353)	1235991..1236299	-	309	WP_218261493.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1229495..1230445	950

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14913.43 Da
• Isoelectric Point: 4.9059

>T207667 WP_218261487.1 NZ_CP077717:1231180-1231572 [Saccharolobus shibatae B12]
MIVVDTNVLVYATFEDSKYHKESVNIIQREDVIIPQIVVYEYLKVLSELVPDLNFVKTKTEELTEFNIVCEDMNIILQAI
NLIKNTKLSLKNINDFIILSFSLYTKSSLATFDVKLRKLAEKNGVNVLPS

Nucleotide

• Length: 393 bp

>T207667 NZ_CP103468:2225955-2226058 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9000.32 Da
• Isoelectric Point: 6.3727

>AT207667 WP_218260056.1 NZ_CP077717:1230960-1231193 [Saccharolobus shibatae B12]
MKRNVSKVTRNYQLTIPLEIREFLGIKEGEYVEFEIDDGKVVIKPLRKKWSTVKLRKQVSVEEIEEIANSAFENDSS

Nucleotide

• Length: 234 bp

>AT207667 NZ_CP103468:c2226096-2225825 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT