Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 1555104..1555710 Replicon chromosome
Accession NZ_CP077715
Organism Saccharolobus shibatae strain BEU9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5U21_RS08640 Protein ID WP_218257805.1
Coordinates 1555104..1555496 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5U21_RS08645 Protein ID WP_218260539.1
Coordinates 1555486..1555710 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5U21_RS15535 (J5U21_01761) 1554853..1555065 + 213 WP_261310580.1 hypothetical protein -
J5U21_RS08640 (J5U21_01762) 1555104..1555496 - 393 WP_218257805.1 type II toxin-antitoxin system VapC family toxin Toxin
J5U21_RS08645 (J5U21_01763) 1555486..1555710 - 225 WP_218260539.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J5U21_RS08650 1555828..1556078 - 251 Protein_1679 IS6 family transposase -
J5U21_RS08655 (J5U21_01766) 1556730..1557047 - 318 WP_261310581.1 clan AA aspartic protease -
J5U21_RS08660 (J5U21_01767) 1557048..1558004 - 957 WP_218260540.1 putative CRISPR-associated protein -
J5U21_RS15540 (J5U21_01768) 1558698..1558859 - 162 WP_261310582.1 hypothetical protein -
J5U21_RS15545 (J5U21_01769) 1559043..1559330 - 288 WP_244988763.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1559740..1560942 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-51)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15128.84 Da        Isoelectric Point: 9.0292

>T207665 WP_218257805.1 NZ_CP077715:c1555496-1555104 [Saccharolobus shibatae]
MKDKEFLLDASALYSLLDYVDKVDVKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVVEDPPLEGV
MRIAIERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T207665 NZ_CP103468:985200-985607 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8786.14 Da        Isoelectric Point: 5.3410

>AT207665 WP_218260539.1 NZ_CP077715:c1555710-1555486 [Saccharolobus shibatae]
MSDVISVRVKKELKKKAEELGINIREVVEKALEEAIKEKEKEELKNTAMKIKELMRDVSEDDWVRTVRESRDER

Download         Length: 225 bp

>AT207665 NZ_CP103468:984953-985219 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References