Detailed information of TA system TA207664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1309119..1309725
• Replicon: chromosome
• Accession: NZ_CP077715
• Organism: Saccharolobus shibatae strain BEU9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J5U21_RS07450
• Protein ID: WP_261310634.1
• Coordinates: 1309119..1309493 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J5U21_RS07455
• Protein ID: WP_218260075.1
• Coordinates: 1309504..1309725 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5U21_RS07425 (J5U21_01478)	1304342..1304614	-	273	WP_218260072.1	hypothetical protein	-
J5U21_RS07430 (J5U21_01479)	1304678..1304923	+	246	WP_261310631.1	hypothetical protein	-
J5U21_RS15455	1305132..1305398	+	267	WP_261310632.1	hypothetical protein	-
J5U21_RS07435 (J5U21_01481)	1305676..1306938	+	1263	WP_218261498.1	ATP-binding protein	-
J5U21_RS07440	1307170..1307502	+	333	WP_261310633.1	hypothetical protein	-
J5U21_RS07445 (J5U21_01483)	1307487..1308689	-	1203	WP_218261499.1	hypothetical protein	-
J5U21_RS07450 (J5U21_01484)	1309119..1309493	-	375	WP_261310634.1	type II toxin-antitoxin system VapC family toxin	Toxin
J5U21_RS07455 (J5U21_01485)	1309504..1309725	-	222	WP_218260075.1	hypothetical protein	Antitoxin
J5U21_RS07460 (J5U21_01486)	1309901..1311130	+	1230	WP_218261500.1	RNA-guided endonuclease TnpB family protein	-
J5U21_RS07465 (J5U21_01487)	1311573..1312728	+	1156	Protein_1436	RNA-guided endonuclease TnpB family protein	-
J5U21_RS07470	1312900..1313947	+	1048	Protein_1437	ISH3 family transposase	-
J5U21_RS07475 (J5U21_01491)	1313963..1314280	-	318	WP_218261501.1	hypothetical protein	-
J5U21_RS15460 (J5U21_01492)	1314349..1314648	-	300	WP_261310635.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (2-117)

Antitoxin

• Putative antitoxin VapB3-like (1-72)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14204.76 Da
• Isoelectric Point: 9.5635

>T207664 WP_261310634.1 NZ_CP077715:c1309493-1309119 [Saccharolobus shibatae]
MAKFVTKEKGWEKIIEILKDAETSDFALAEVSNVVWKKTVLTRELTKQDAIKAVAIIRYYLPQLLTLNKSIDVIERAIEI
SIIEKIPIYDSLYIALAERKGSKLVTGDRKQHEIAKKYVISELI

Nucleotide

• Length: 375 bp

>T207664 NZ_CP103468:c844754-844377 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 9035.28 Da
• Isoelectric Point: 4.9835

>AT207664 WP_218260075.1 NZ_CP077715:c1309725-1309504 [Saccharolobus shibatae]
MKTVYSLRIDKELREEMEKYNVKWNEEIENFIRRRIEELKKEEIFKKINEILQTMPETKSNSAELVREDRDNS

Nucleotide

• Length: 222 bp

>AT207664 NZ_CP103468:c845212-844844 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA