Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1290100..1290712 Replicon chromosome
Accession NZ_CP077715
Organism Saccharolobus shibatae strain BEU9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5U21_RS07310 Protein ID WP_218261487.1
Coordinates 1290320..1290712 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5U21_RS07305 Protein ID WP_218260056.1
Coordinates 1290100..1290333 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5U21_RS07285 (J5U21_01450) 1285869..1287683 - 1815 WP_218261484.1 phosphoenolpyruvate carboxykinase (GTP) -
J5U21_RS07290 (J5U21_01451) 1287969..1288175 + 207 WP_218261485.1 hypothetical protein -
J5U21_RS07295 (J5U21_01452) 1288443..1288631 - 189 WP_218261486.1 hypothetical protein -
J5U21_RS07300 (J5U21_01453) 1288844..1289542 + 699 WP_218260054.1 TIGR00266 family protein -
J5U21_RS07305 (J5U21_01454) 1290100..1290333 + 234 WP_218260056.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J5U21_RS07310 (J5U21_01455) 1290320..1290712 + 393 WP_218261487.1 PIN domain-containing protein Toxin
J5U21_RS07315 (J5U21_01457) 1291265..1291786 + 522 WP_218260058.1 hypothetical protein -
J5U21_RS07320 (J5U21_01458) 1292109..1292537 + 429 WP_218261488.1 HEPN domain-containing protein -
J5U21_RS07325 (J5U21_01459) 1292500..1292940 + 441 WP_218261489.1 nucleotidyltransferase domain-containing protein -
J5U21_RS15450 1293358..1293492 - 135 Protein_1407 transposase -
J5U21_RS07330 (J5U21_01460) 1293729..1293959 + 231 WP_218261490.1 CopG family transcriptional regulator -
J5U21_RS07335 (J5U21_01461) 1293956..1294345 + 390 WP_218261491.1 type II toxin-antitoxin system VapC family toxin -
J5U21_RS07340 (J5U21_01462) 1294437..1294676 + 240 WP_218261492.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
J5U21_RS07345 (J5U21_01463) 1295141..1295449 - 309 WP_218261493.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14913.43 Da        Isoelectric Point: 4.9059

>T207663 WP_218261487.1 NZ_CP077715:1290320-1290712 [Saccharolobus shibatae]
MIVVDTNVLVYATFEDSKYHKESVNIIQREDVIIPQIVVYEYLKVLSELVPDLNFVKTKTEELTEFNIVCEDMNIILQAI
NLIKNTKLSLKNINDFIILSFSLYTKSSLATFDVKLRKLAEKNGVNVLPS

Download         Length: 393 bp

>T207663 NZ_CP103468:c632858-632394 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9000.32 Da        Isoelectric Point: 6.3727

>AT207663 WP_218260056.1 NZ_CP077715:1290100-1290333 [Saccharolobus shibatae]
MKRNVSKVTRNYQLTIPLEIREFLGIKEGEYVEFEIDDGKVVIKPLRKKWSTVKLRKQVSVEEIEEIANSAFENDSS

Download         Length: 234 bp

>AT207663 NZ_CP103468:c633193-632858 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References